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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN21
All Species:
26.06
Human Site:
S374
Identified Species:
52.12
UniProt:
Q16825
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16825
NP_008970.2
1174
133281
S374
Q
N
G
Y
Y
C
H
S
Q
T
S
L
D
R
A
Chimpanzee
Pan troglodytes
XP_510107
1174
133325
S374
Q
N
G
Y
Y
C
H
S
Q
T
S
L
D
R
A
Rhesus Macaque
Macaca mulatta
XP_001083418
1174
133288
S374
Q
N
G
Y
Y
C
H
S
Q
T
S
L
D
R
A
Dog
Lupus familis
XP_547945
1170
132251
S374
Q
N
G
Y
Y
C
H
S
L
T
S
L
D
R
A
Cat
Felis silvestris
Mouse
Mus musculus
Q62136
1176
133472
S374
K
N
G
F
Y
C
H
S
Q
T
S
L
D
R
T
Rat
Rattus norvegicus
Q62728
1175
133393
S374
K
N
G
F
Y
C
H
S
Q
T
S
L
D
R
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516721
825
93182
G101
V
M
R
Q
L
N
R
G
M
I
H
A
E
R
Q
Chicken
Gallus gallus
XP_421308
1185
135558
S374
Q
N
G
Y
Y
Y
H
S
Q
T
S
L
D
R
A
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001339962
834
94004
R110
A
L
I
P
P
S
Y
R
A
T
P
D
Y
E
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V8R9
1698
184149
R380
A
E
K
E
K
V
A
R
K
S
S
T
L
D
H
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P28191
1026
115075
K302
K
I
C
K
L
L
W
K
C
C
I
E
Q
H
T
Sea Urchin
Strong. purpuratus
XP_796215
1318
147575
D374
L
P
H
H
M
M
A
D
G
Q
L
G
N
Q
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
97.9
89.4
N.A.
89
88
N.A.
58.6
85.1
N.A.
51.8
N.A.
20.2
N.A.
26.1
34.7
Protein Similarity:
100
99.4
98.7
93.1
N.A.
93
92.5
N.A.
63.3
91.8
N.A.
59.4
N.A.
37
N.A.
42.5
52.5
P-Site Identity:
100
100
100
93.3
N.A.
80
80
N.A.
6.6
93.3
N.A.
6.6
N.A.
6.6
N.A.
0
0
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
13.3
93.3
N.A.
13.3
N.A.
20
N.A.
6.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
17
0
0
0
0
0
17
0
9
0
0
9
0
0
42
% A
% Cys:
0
0
9
0
0
50
0
0
9
9
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
9
0
0
0
9
59
9
0
% D
% Glu:
0
9
0
9
0
0
0
0
0
0
0
9
9
9
0
% E
% Phe:
0
0
0
17
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
59
0
0
0
0
9
9
0
0
9
0
0
0
% G
% His:
0
0
9
9
0
0
59
0
0
0
9
0
0
9
9
% H
% Ile:
0
9
9
0
0
0
0
0
0
9
9
0
0
0
0
% I
% Lys:
25
0
9
9
9
0
0
9
9
0
0
0
0
0
0
% K
% Leu:
9
9
0
0
17
9
0
0
9
0
9
59
9
0
0
% L
% Met:
0
9
0
0
9
9
0
0
9
0
0
0
0
0
0
% M
% Asn:
0
59
0
0
0
9
0
0
0
0
0
0
9
0
0
% N
% Pro:
0
9
0
9
9
0
0
0
0
0
9
0
0
0
0
% P
% Gln:
42
0
0
9
0
0
0
0
50
9
0
0
9
9
17
% Q
% Arg:
0
0
9
0
0
0
9
17
0
0
0
0
0
67
0
% R
% Ser:
0
0
0
0
0
9
0
59
0
9
67
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
67
0
9
0
0
34
% T
% Val:
9
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
42
59
9
9
0
0
0
0
0
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _