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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN21
All Species:
28.48
Human Site:
S399
Identified Species:
56.97
UniProt:
Q16825
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16825
NP_008970.2
1174
133281
S399
G
S
V
Y
S
A
H
S
T
N
S
L
N
N
P
Chimpanzee
Pan troglodytes
XP_510107
1174
133325
S399
G
S
V
Y
S
A
H
S
T
N
S
L
N
N
P
Rhesus Macaque
Macaca mulatta
XP_001083418
1174
133288
S399
G
S
V
Y
S
A
H
S
T
N
S
L
N
N
P
Dog
Lupus familis
XP_547945
1170
132251
S399
G
S
V
Y
S
A
H
S
T
N
S
L
N
N
P
Cat
Felis silvestris
Mouse
Mus musculus
Q62136
1176
133472
S399
G
S
V
Y
S
A
H
S
T
N
S
L
N
T
L
Rat
Rattus norvegicus
Q62728
1175
133393
S399
G
S
V
Y
S
A
H
S
T
N
S
L
N
T
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516721
825
93182
R125
S
N
S
Y
A
Y
S
R
P
D
A
L
V
Y
S
Chicken
Gallus gallus
XP_421308
1185
135558
S399
G
S
V
Y
S
A
H
S
T
N
S
L
N
N
P
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001339962
834
94004
S134
A
A
E
R
Q
S
H
S
M
R
N
L
N
I
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V8R9
1698
184149
A540
L
D
E
A
A
R
N
A
A
K
N
R
G
S
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P28191
1026
115075
N326
T
P
Q
R
K
V
F
N
F
G
S
K
F
R
Y
Sea Urchin
Strong. purpuratus
XP_796215
1318
147575
N437
N
L
V
M
L
D
Q
N
G
S
V
Y
S
A
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
97.9
89.4
N.A.
89
88
N.A.
58.6
85.1
N.A.
51.8
N.A.
20.2
N.A.
26.1
34.7
Protein Similarity:
100
99.4
98.7
93.1
N.A.
93
92.5
N.A.
63.3
91.8
N.A.
59.4
N.A.
37
N.A.
42.5
52.5
P-Site Identity:
100
100
100
100
N.A.
86.6
93.3
N.A.
13.3
100
N.A.
26.6
N.A.
0
N.A.
6.6
13.3
P-Site Similarity:
100
100
100
100
N.A.
86.6
93.3
N.A.
40
100
N.A.
46.6
N.A.
33.3
N.A.
13.3
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
9
0
9
17
59
0
9
9
0
9
0
0
9
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
9
0
0
0
9
0
0
0
9
0
0
0
0
0
% D
% Glu:
0
0
17
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
9
0
9
0
0
0
9
0
0
% F
% Gly:
59
0
0
0
0
0
0
0
9
9
0
0
9
0
9
% G
% His:
0
0
0
0
0
0
67
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% I
% Lys:
0
0
0
0
9
0
0
0
0
9
0
9
0
0
0
% K
% Leu:
9
9
0
0
9
0
0
0
0
0
0
75
0
0
9
% L
% Met:
0
0
0
9
0
0
0
0
9
0
0
0
0
0
0
% M
% Asn:
9
9
0
0
0
0
9
17
0
59
17
0
67
42
0
% N
% Pro:
0
9
0
0
0
0
0
0
9
0
0
0
0
0
59
% P
% Gln:
0
0
9
0
9
0
9
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
17
0
9
0
9
0
9
0
9
0
9
0
% R
% Ser:
9
59
9
0
59
9
9
67
0
9
67
0
9
9
9
% S
% Thr:
9
0
0
0
0
0
0
0
59
0
0
0
0
17
9
% T
% Val:
0
0
67
0
0
9
0
0
0
0
9
0
9
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
67
0
9
0
0
0
0
0
9
0
9
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _