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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN21
All Species:
27.58
Human Site:
T453
Identified Species:
55.15
UniProt:
Q16825
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16825
NP_008970.2
1174
133281
T453
R
P
T
P
D
Y
E
T
V
M
K
Q
L
N
R
Chimpanzee
Pan troglodytes
XP_510107
1174
133325
T453
R
P
T
P
D
Y
E
T
V
M
K
Q
L
N
R
Rhesus Macaque
Macaca mulatta
XP_001083418
1174
133288
T453
R
P
T
P
D
Y
E
T
V
M
K
Q
L
N
R
Dog
Lupus familis
XP_547945
1170
132251
T453
R
P
T
P
D
Y
E
T
V
M
K
Q
L
N
R
Cat
Felis silvestris
Mouse
Mus musculus
Q62136
1176
133472
T453
R
P
T
P
D
Y
E
T
V
M
K
Q
L
N
R
Rat
Rattus norvegicus
Q62728
1175
133393
S453
R
P
T
P
D
Y
E
S
V
M
K
R
L
N
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516721
825
93182
V179
P
V
V
G
A
V
S
V
P
E
L
T
N
V
Q
Chicken
Gallus gallus
XP_421308
1185
135558
T453
R
P
T
P
D
Y
E
T
V
M
R
Q
L
N
R
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001339962
834
94004
R188
Y
P
Y
P
T
E
R
R
P
V
V
G
A
V
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V8R9
1698
184149
E594
K
S
G
A
D
G
Q
E
Q
L
S
P
T
S
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P28191
1026
115075
S380
N
T
Q
S
I
D
S
S
R
Y
T
N
T
T
T
Sea Urchin
Strong. purpuratus
XP_796215
1318
147575
A491
R
Q
S
P
D
Y
E
A
F
I
Q
A
R
L
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
97.9
89.4
N.A.
89
88
N.A.
58.6
85.1
N.A.
51.8
N.A.
20.2
N.A.
26.1
34.7
Protein Similarity:
100
99.4
98.7
93.1
N.A.
93
92.5
N.A.
63.3
91.8
N.A.
59.4
N.A.
37
N.A.
42.5
52.5
P-Site Identity:
100
100
100
100
N.A.
100
86.6
N.A.
0
93.3
N.A.
13.3
N.A.
6.6
N.A.
0
33.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
6.6
100
N.A.
20
N.A.
40
N.A.
6.6
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
9
9
0
0
9
0
0
0
9
9
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
75
9
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
9
67
9
0
9
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% F
% Gly:
0
0
9
9
0
9
0
0
0
0
0
9
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
9
0
0
0
0
9
0
0
0
0
0
% I
% Lys:
9
0
0
0
0
0
0
0
0
0
50
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
9
9
0
59
9
0
% L
% Met:
0
0
0
0
0
0
0
0
0
59
0
0
0
0
0
% M
% Asn:
9
0
0
0
0
0
0
0
0
0
0
9
9
59
0
% N
% Pro:
9
67
0
75
0
0
0
0
17
0
0
9
0
0
0
% P
% Gln:
0
9
9
0
0
0
9
0
9
0
9
50
0
0
25
% Q
% Arg:
67
0
0
0
0
0
9
9
9
0
9
9
9
0
59
% R
% Ser:
0
9
9
9
0
0
17
17
0
0
9
0
0
9
9
% S
% Thr:
0
9
59
0
9
0
0
50
0
0
9
9
17
9
9
% T
% Val:
0
9
9
0
0
9
0
9
59
9
9
0
0
17
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
0
9
0
0
67
0
0
0
9
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _