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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PTPN21 All Species: 11.21
Human Site: T682 Identified Species: 22.42
UniProt: Q16825 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q16825 NP_008970.2 1174 133281 T682 P S V F T E R T Q R E G P E E
Chimpanzee Pan troglodytes XP_510107 1174 133325 T682 P S V F T E R T Q R E G P E E
Rhesus Macaque Macaca mulatta XP_001083418 1174 133288 T682 P S V F T E R T K R E G Q E E
Dog Lupus familis XP_547945 1170 132251 A682 P G G F P E R A E R D Q A D E
Cat Felis silvestris
Mouse Mus musculus Q62136 1176 133472 M682 S S V F S D K M K Q E G T E E
Rat Rattus norvegicus Q62728 1175 133393 V682 S S V F S D K V K Q E G T E E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516721 825 93182 I407 P V P S S L H I C E P K I H V
Chicken Gallus gallus XP_421308 1185 135558 R682 Q P N V L I E R T K Q K E N E
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001339962 834 94004 P416 G R S L G D P P A Y P F S H S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9V8R9 1698 184149 T838 G T L E A L N T K T G K K E V
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P28191 1026 115075 S608 P Q S N K S S S P V G E D Q V
Sea Urchin Strong. purpuratus XP_796215 1318 147575 D732 T D K A Q P S D L S M I A V P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 97.9 89.4 N.A. 89 88 N.A. 58.6 85.1 N.A. 51.8 N.A. 20.2 N.A. 26.1 34.7
Protein Similarity: 100 99.4 98.7 93.1 N.A. 93 92.5 N.A. 63.3 91.8 N.A. 59.4 N.A. 37 N.A. 42.5 52.5
P-Site Identity: 100 100 86.6 40 N.A. 46.6 46.6 N.A. 6.6 6.6 N.A. 0 N.A. 13.3 N.A. 6.6 0
P-Site Similarity: 100 100 93.3 60 N.A. 80 80 N.A. 13.3 20 N.A. 6.6 N.A. 33.3 N.A. 20 0
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 9 9 0 0 9 9 0 0 0 17 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 9 0 0 0 0 0 0 % C
% Asp: 0 9 0 0 0 25 0 9 0 0 9 0 9 9 0 % D
% Glu: 0 0 0 9 0 34 9 0 9 9 42 9 9 50 59 % E
% Phe: 0 0 0 50 0 0 0 0 0 0 0 9 0 0 0 % F
% Gly: 17 9 9 0 9 0 0 0 0 0 17 42 0 0 0 % G
% His: 0 0 0 0 0 0 9 0 0 0 0 0 0 17 0 % H
% Ile: 0 0 0 0 0 9 0 9 0 0 0 9 9 0 0 % I
% Lys: 0 0 9 0 9 0 17 0 34 9 0 25 9 0 0 % K
% Leu: 0 0 9 9 9 17 0 0 9 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 9 0 0 9 0 0 0 0 % M
% Asn: 0 0 9 9 0 0 9 0 0 0 0 0 0 9 0 % N
% Pro: 50 9 9 0 9 9 9 9 9 0 17 0 17 0 9 % P
% Gln: 9 9 0 0 9 0 0 0 17 17 9 9 9 9 0 % Q
% Arg: 0 9 0 0 0 0 34 9 0 34 0 0 0 0 0 % R
% Ser: 17 42 17 9 25 9 17 9 0 9 0 0 9 0 9 % S
% Thr: 9 9 0 0 25 0 0 34 9 9 0 0 17 0 0 % T
% Val: 0 9 42 9 0 0 0 9 0 9 0 0 0 9 25 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 9 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _