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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN21
All Species:
28.79
Human Site:
Y121
Identified Species:
57.58
UniProt:
Q16825
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16825
NP_008970.2
1174
133281
Y121
E
I
T
R
Y
Q
Y
Y
L
Q
L
K
K
D
I
Chimpanzee
Pan troglodytes
XP_510107
1174
133325
Y121
E
I
T
R
Y
Q
Y
Y
L
Q
L
K
K
D
I
Rhesus Macaque
Macaca mulatta
XP_001083418
1174
133288
Y121
E
I
T
R
Y
Q
Y
Y
L
Q
L
K
K
D
I
Dog
Lupus familis
XP_547945
1170
132251
Y121
E
I
T
R
Y
Q
Y
Y
L
Q
L
K
K
D
I
Cat
Felis silvestris
Mouse
Mus musculus
Q62136
1176
133472
Y121
E
I
T
R
Y
Q
Y
Y
L
Q
L
K
K
D
I
Rat
Rattus norvegicus
Q62728
1175
133393
Y121
E
I
T
R
Y
Q
Y
Y
L
Q
L
K
K
D
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516721
825
93182
Chicken
Gallus gallus
XP_421308
1185
135558
Y121
E
I
T
R
Y
Q
Y
Y
L
Q
L
K
K
D
I
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001339962
834
94004
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V8R9
1698
184149
C128
D
I
T
R
Y
H
L
C
L
Q
V
R
N
D
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P28191
1026
115075
S81
F
I
A
V
D
N
S
S
A
Q
Q
K
K
W
L
Sea Urchin
Strong. purpuratus
XP_796215
1318
147575
F119
E
M
T
R
Y
M
Y
F
L
Q
L
K
S
D
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
97.9
89.4
N.A.
89
88
N.A.
58.6
85.1
N.A.
51.8
N.A.
20.2
N.A.
26.1
34.7
Protein Similarity:
100
99.4
98.7
93.1
N.A.
93
92.5
N.A.
63.3
91.8
N.A.
59.4
N.A.
37
N.A.
42.5
52.5
P-Site Identity:
100
100
100
100
N.A.
100
93.3
N.A.
0
100
N.A.
0
N.A.
53.3
N.A.
26.6
66.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
0
100
N.A.
0
N.A.
73.3
N.A.
33.3
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
0
0
0
0
0
9
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% C
% Asp:
9
0
0
0
9
0
0
0
0
0
0
0
0
75
0
% D
% Glu:
67
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
9
0
0
0
0
0
0
9
0
0
0
0
0
0
9
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
75
0
0
0
0
0
0
0
0
0
0
0
0
59
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
75
67
0
0
% K
% Leu:
0
0
0
0
0
0
9
0
75
0
67
0
0
0
9
% L
% Met:
0
9
0
0
0
9
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
9
0
0
0
0
0
0
9
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
59
0
0
0
84
9
0
0
0
0
% Q
% Arg:
0
0
0
75
0
0
0
0
0
0
0
9
0
0
0
% R
% Ser:
0
0
0
0
0
0
9
9
0
0
0
0
9
0
0
% S
% Thr:
0
0
75
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
9
0
0
0
0
0
0
9
0
0
0
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% W
% Tyr:
0
0
0
0
75
0
67
59
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _