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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN21
All Species:
30
Human Site:
Y445
Identified Species:
60
UniProt:
Q16825
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16825
NP_008970.2
1174
133281
Y445
S
A
V
I
P
P
S
Y
R
P
T
P
D
Y
E
Chimpanzee
Pan troglodytes
XP_510107
1174
133325
Y445
S
A
L
I
P
P
S
Y
R
P
T
P
D
Y
E
Rhesus Macaque
Macaca mulatta
XP_001083418
1174
133288
Y445
S
A
L
I
P
P
S
Y
R
P
T
P
D
Y
E
Dog
Lupus familis
XP_547945
1170
132251
Y445
S
A
L
V
P
P
S
Y
R
P
T
P
D
Y
E
Cat
Felis silvestris
Mouse
Mus musculus
Q62136
1176
133472
Y445
S
A
L
I
P
P
S
Y
R
P
T
P
D
Y
E
Rat
Rattus norvegicus
Q62728
1175
133393
Y445
S
A
L
I
P
P
S
Y
R
P
T
P
D
Y
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516721
825
93182
R171
S
P
H
P
A
E
R
R
P
V
V
G
A
V
S
Chicken
Gallus gallus
XP_421308
1185
135558
Y445
S
A
L
I
P
P
S
Y
R
P
T
P
D
Y
E
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001339962
834
94004
P180
Y
S
F
H
S
P
S
P
Y
P
Y
P
T
E
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V8R9
1698
184149
R586
Y
D
Q
D
P
N
S
R
K
S
G
A
D
G
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P28191
1026
115075
G372
F
L
R
S
T
F
S
G
N
T
Q
S
I
D
S
Sea Urchin
Strong. purpuratus
XP_796215
1318
147575
Y483
L
Q
A
S
L
P
A
Y
R
Q
S
P
D
Y
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
97.9
89.4
N.A.
89
88
N.A.
58.6
85.1
N.A.
51.8
N.A.
20.2
N.A.
26.1
34.7
Protein Similarity:
100
99.4
98.7
93.1
N.A.
93
92.5
N.A.
63.3
91.8
N.A.
59.4
N.A.
37
N.A.
42.5
52.5
P-Site Identity:
100
93.3
93.3
86.6
N.A.
93.3
93.3
N.A.
6.6
93.3
N.A.
26.6
N.A.
20
N.A.
6.6
46.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
6.6
100
N.A.
33.3
N.A.
33.3
N.A.
6.6
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
59
9
0
9
0
9
0
0
0
0
9
9
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
9
0
9
0
0
0
0
0
0
0
0
75
9
0
% D
% Glu:
0
0
0
0
0
9
0
0
0
0
0
0
0
9
67
% E
% Phe:
9
0
9
0
0
9
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
9
0
0
9
9
0
9
0
% G
% His:
0
0
9
9
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
50
0
0
0
0
0
0
0
0
9
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% K
% Leu:
9
9
50
0
9
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
9
0
0
9
0
0
0
0
0
0
% N
% Pro:
0
9
0
9
67
75
0
9
9
67
0
75
0
0
0
% P
% Gln:
0
9
9
0
0
0
0
0
0
9
9
0
0
0
9
% Q
% Arg:
0
0
9
0
0
0
9
17
67
0
0
0
0
0
9
% R
% Ser:
67
9
0
17
9
0
84
0
0
9
9
9
0
0
17
% S
% Thr:
0
0
0
0
9
0
0
0
0
9
59
0
9
0
0
% T
% Val:
0
0
9
9
0
0
0
0
0
9
9
0
0
9
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
17
0
0
0
0
0
0
67
9
0
9
0
0
67
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _