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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PTPN21 All Species: 20
Human Site: Y695 Identified Species: 40
UniProt: Q16825 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q16825 NP_008970.2 1174 133281 Y695 E E A E G L R Y G H K K S L S
Chimpanzee Pan troglodytes XP_510107 1174 133325 Y695 E E A E G L R Y G H K K S L S
Rhesus Macaque Macaca mulatta XP_001083418 1174 133288 Y695 E E A E G L R Y G H E K S L S
Dog Lupus familis XP_547945 1170 132251 Y695 D E R G G L A Y G H K K S L S
Cat Felis silvestris
Mouse Mus musculus Q62136 1176 133472 Y695 E E Q E G G R Y S H K K S L S
Rat Rattus norvegicus Q62728 1175 133393 Y695 E E Q G S G G Y S H K K S L S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516721 825 93182 R420 H V M E S E K R V R D V S P V
Chicken Gallus gallus XP_421308 1185 135558 N695 N E Q D E G V N C D H K K T L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001339962 834 94004 T429 H S M E T V L T S P P A Y Q A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9V8R9 1698 184149 D851 E V F Q G D V D G K T G N L H
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P28191 1026 115075 R621 Q V V T I K M R P D R H G R F
Sea Urchin Strong. purpuratus XP_796215 1318 147575 N745 V P T G Y E D N L P T P P D K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 97.9 89.4 N.A. 89 88 N.A. 58.6 85.1 N.A. 51.8 N.A. 20.2 N.A. 26.1 34.7
Protein Similarity: 100 99.4 98.7 93.1 N.A. 93 92.5 N.A. 63.3 91.8 N.A. 59.4 N.A. 37 N.A. 42.5 52.5
P-Site Identity: 100 100 93.3 73.3 N.A. 80 60 N.A. 13.3 13.3 N.A. 6.6 N.A. 26.6 N.A. 0 0
P-Site Similarity: 100 100 100 80 N.A. 80 60 N.A. 20 20 N.A. 20 N.A. 40 N.A. 13.3 0
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 25 0 0 0 9 0 0 0 0 9 0 0 9 % A
% Cys: 0 0 0 0 0 0 0 0 9 0 0 0 0 0 0 % C
% Asp: 9 0 0 9 0 9 9 9 0 17 9 0 0 9 0 % D
% Glu: 50 59 0 50 9 17 0 0 0 0 9 0 0 0 0 % E
% Phe: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 9 % F
% Gly: 0 0 0 25 50 25 9 0 42 0 0 9 9 0 0 % G
% His: 17 0 0 0 0 0 0 0 0 50 9 9 0 0 9 % H
% Ile: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 9 9 0 0 9 42 59 9 0 9 % K
% Leu: 0 0 0 0 0 34 9 0 9 0 0 0 0 59 9 % L
% Met: 0 0 17 0 0 0 9 0 0 0 0 0 0 0 0 % M
% Asn: 9 0 0 0 0 0 0 17 0 0 0 0 9 0 0 % N
% Pro: 0 9 0 0 0 0 0 0 9 17 9 9 9 9 0 % P
% Gln: 9 0 25 9 0 0 0 0 0 0 0 0 0 9 0 % Q
% Arg: 0 0 9 0 0 0 34 17 0 9 9 0 0 9 0 % R
% Ser: 0 9 0 0 17 0 0 0 25 0 0 0 59 0 50 % S
% Thr: 0 0 9 9 9 0 0 9 0 0 17 0 0 9 0 % T
% Val: 9 25 9 0 0 9 17 0 9 0 0 9 0 0 9 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 9 0 0 50 0 0 0 0 9 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _