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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DUSP6 All Species: 18.18
Human Site: S176 Identified Species: 44.44
UniProt: Q16828 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q16828 NP_001937.2 381 42320 S176 G L R I S S D S S S D I E S D
Chimpanzee Pan troglodytes XP_526209 468 50775 S263 L G G L R I S S D C S D G E S
Rhesus Macaque Macaca mulatta XP_001091142 368 40570 S163 L G G L R I S S D C S D G E S
Dog Lupus familis XP_852241 381 42285 S176 G L R I S S D S S S D I E S D
Cat Felis silvestris
Mouse Mus musculus Q9DBB1 381 42389 S176 G L R I S S D S S S D I E S D
Rat Rattus norvegicus Q64346 381 42300 S176 G L R I S S D S S S D I E S D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506331 383 42666 S178 G L G G L R I S S D C S D G E
Chicken Gallus gallus Q9PW71 375 41034 G175 G T P L H D Q G G P V E I L P
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres NP_001163824 383 42813 D176 G G L R I S S D S S D I E S D
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_794377 403 44845 S154 Q T S E D S D S D E C S L T D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 58.5 70 99.7 N.A. 98.1 98.6 N.A. 71 37.5 N.A. N.A. 80.4 N.A. N.A. N.A. 45.4
Protein Similarity: 100 70.3 83.4 100 N.A. 98.9 99.4 N.A. 86.6 53.8 N.A. N.A. 88.7 N.A. N.A. N.A. 59.3
P-Site Identity: 100 6.6 6.6 100 N.A. 100 100 N.A. 26.6 6.6 N.A. N.A. 60 N.A. N.A. N.A. 26.6
P-Site Similarity: 100 13.3 13.3 100 N.A. 100 100 N.A. 40 13.3 N.A. N.A. 60 N.A. N.A. N.A. 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 20 20 0 0 0 0 % C
% Asp: 0 0 0 0 10 10 50 10 30 10 50 20 10 0 60 % D
% Glu: 0 0 0 10 0 0 0 0 0 10 0 10 50 20 10 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 70 30 30 10 0 0 0 10 10 0 0 0 20 10 0 % G
% His: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 40 10 20 10 0 0 0 0 50 10 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 20 50 10 30 10 0 0 0 0 0 0 0 10 10 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 10 0 0 0 0 0 0 10 0 0 0 0 10 % P
% Gln: 10 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 40 10 20 10 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 10 0 40 60 30 80 60 50 20 20 0 50 20 % S
% Thr: 0 20 0 0 0 0 0 0 0 0 0 0 0 10 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _