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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HADH All Species: 31.52
Human Site: S15 Identified Species: 63.03
UniProt: Q16836 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q16836 NP_005318.2 314 34278 S15 F M R S V S S S S T A S A S A
Chimpanzee Pan troglodytes XP_517385 390 42181 S74 L M R S V S S S S T A S A S A
Rhesus Macaque Macaca mulatta XP_001084834 496 54433 S180 F M R S M S S S S T A S A S A
Dog Lupus familis XP_535685 312 34317 S15 F V R S V S S S S T A S A K K
Cat Felis silvestris
Mouse Mus musculus Q61425 314 34445 S15 F L R S M S S S S S A S A A A
Rat Rattus norvegicus Q9WVK7 314 34429 S15 F V R S M S S S S S A S A A A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511764 360 39012 R59 G H R A L T G R E S G A A S F
Chicken Gallus gallus XP_418403 315 34403 T16 V R A A S S A T A A A T A A A
Frog Xenopus laevis NP_001080900 313 34295 S15 Q L L A R C M S T A P A A A K
Zebra Danio Brachydanio rerio NP_001003515 309 33318 S15 F S R S F S S S Q A L H H T I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P41938 309 33362 T16 A V R G L S T T A Q L S K I N
Sea Urchin Strong. purpuratus XP_787188 292 31577 M15 T I V G G G Q M G A G I A Q V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 80 61.4 92.3 N.A. 90.1 90.4 N.A. 70 77.7 79.3 76.1 N.A. N.A. N.A. 53.8 58.6
Protein Similarity: 100 80 62.7 97.7 N.A. 97.1 97.1 N.A. 79.1 90.1 87.9 84.7 N.A. N.A. N.A. 67.1 74.5
P-Site Identity: 100 93.3 93.3 80 N.A. 73.3 73.3 N.A. 20 26.6 13.3 40 N.A. N.A. N.A. 20 6.6
P-Site Similarity: 100 93.3 100 86.6 N.A. 100 100 N.A. 53.3 66.6 46.6 46.6 N.A. N.A. N.A. 53.3 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 0 9 25 0 0 9 0 17 34 59 17 84 34 50 % A
% Cys: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 9 0 0 0 0 0 0 % E
% Phe: 50 0 0 0 9 0 0 0 0 0 0 0 0 0 9 % F
% Gly: 9 0 0 17 9 9 9 0 9 0 17 0 0 0 0 % G
% His: 0 9 0 0 0 0 0 0 0 0 0 9 9 0 0 % H
% Ile: 0 9 0 0 0 0 0 0 0 0 0 9 0 9 9 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 9 9 17 % K
% Leu: 9 17 9 0 17 0 0 0 0 0 17 0 0 0 0 % L
% Met: 0 25 0 0 25 0 9 9 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % P
% Gln: 9 0 0 0 0 0 9 0 9 9 0 0 0 9 0 % Q
% Arg: 0 9 75 0 9 0 0 9 0 0 0 0 0 0 0 % R
% Ser: 0 9 0 59 9 75 59 67 50 25 0 59 0 34 0 % S
% Thr: 9 0 0 0 0 9 9 17 9 34 0 9 0 9 0 % T
% Val: 9 25 9 0 25 0 0 0 0 0 0 0 0 0 9 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _