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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CYP51A1
All Species:
30.91
Human Site:
S161
Identified Species:
52.31
UniProt:
Q16850
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16850
NP_000777.1
503
56806
S161
E
Q
K
K
M
L
K
S
G
L
N
I
A
H
F
Chimpanzee
Pan troglodytes
XP_519193
509
57278
S167
E
Q
K
K
M
L
K
S
G
L
N
I
A
H
F
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532457
503
56745
S161
E
Q
K
K
M
L
K
S
G
L
N
I
A
H
F
Cat
Felis silvestris
Mouse
Mus musculus
Q8K0C4
503
56757
S161
E
Q
K
K
I
I
K
S
G
L
N
I
A
H
F
Rat
Rattus norvegicus
Q64654
503
56688
S161
E
Q
K
K
I
L
K
S
G
L
N
I
A
H
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517490
563
61243
C192
A
P
P
T
A
P
C
C
A
P
G
F
F
S
K
Chicken
Gallus gallus
Q9PUB4
492
55246
V153
R
D
A
L
Q
H
Y
V
P
V
I
Q
E
E
V
Frog
Xenopus laevis
NP_001091285
501
56963
T159
E
Q
K
K
M
L
K
T
G
L
N
I
A
H
F
Zebra Danio
Brachydanio rerio
NP_001001730
499
56983
T153
E
Q
K
K
M
L
K
T
G
L
N
I
A
Q
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P33269
512
58673
H168
M
E
Q
D
R
L
K
H
G
E
S
G
F
S
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001001906
496
56226
T152
E
Q
K
K
M
L
K
T
G
L
N
I
Q
Q
F
Poplar Tree
Populus trichocarpa
XP_002299356
488
55530
A155
V
D
Q
M
V
V
E
A
E
D
Y
F
L
K
W
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LTM7
502
57706
K155
E
E
C
N
L
L
V
K
K
L
T
E
S
A
V
Baker's Yeast
Sacchar. cerevisiae
P10614
530
60702
F163
G
A
L
T
K
E
A
F
K
S
Y
V
P
L
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98
N.A.
96.6
N.A.
91.2
93.4
N.A.
58
23.6
80.3
75.9
N.A.
20.7
N.A.
N.A.
66.8
Protein Similarity:
100
98.6
N.A.
98.6
N.A.
96.6
97.4
N.A.
65.5
42.5
89.4
86.6
N.A.
40.6
N.A.
N.A.
81.3
P-Site Identity:
100
100
N.A.
100
N.A.
86.6
93.3
N.A.
0
0
93.3
86.6
N.A.
20
N.A.
N.A.
80
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
0
6.6
100
93.3
N.A.
40
N.A.
N.A.
86.6
Percent
Protein Identity:
37.9
N.A.
N.A.
20.4
35
N.A.
Protein Similarity:
56.4
N.A.
N.A.
37.3
54.9
N.A.
P-Site Identity:
0
N.A.
N.A.
20
0
N.A.
P-Site Similarity:
40
N.A.
N.A.
40
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
8
0
8
0
8
8
8
0
0
0
50
8
0
% A
% Cys:
0
0
8
0
0
0
8
8
0
0
0
0
0
0
0
% C
% Asp:
0
15
0
8
0
0
0
0
0
8
0
0
0
0
0
% D
% Glu:
65
15
0
0
0
8
8
0
8
8
0
8
8
8
0
% E
% Phe:
0
0
0
0
0
0
0
8
0
0
0
15
15
0
58
% F
% Gly:
8
0
0
0
0
0
0
0
65
0
8
8
0
0
0
% G
% His:
0
0
0
0
0
8
0
8
0
0
0
0
0
43
0
% H
% Ile:
0
0
0
0
15
8
0
0
0
0
8
58
0
0
8
% I
% Lys:
0
0
58
58
8
0
65
8
15
0
0
0
0
8
8
% K
% Leu:
0
0
8
8
8
65
0
0
0
65
0
0
8
8
8
% L
% Met:
8
0
0
8
43
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
8
0
0
0
0
0
0
58
0
0
0
0
% N
% Pro:
0
8
8
0
0
8
0
0
8
8
0
0
8
0
0
% P
% Gln:
0
58
15
0
8
0
0
0
0
0
0
8
8
15
0
% Q
% Arg:
8
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
36
0
8
8
0
8
15
0
% S
% Thr:
0
0
0
15
0
0
0
22
0
0
8
0
0
0
0
% T
% Val:
8
0
0
0
8
8
8
8
0
8
0
8
0
0
15
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% W
% Tyr:
0
0
0
0
0
0
8
0
0
0
15
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _