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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CYP51A1
All Species:
17.88
Human Site:
S185
Identified Species:
30.26
UniProt:
Q16850
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.23
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16850
NP_000777.1
503
56806
S185
E
T
K
E
Y
F
E
S
W
G
E
S
G
E
K
Chimpanzee
Pan troglodytes
XP_519193
509
57278
S191
E
T
K
E
Y
F
Q
S
W
G
E
S
G
E
K
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532457
503
56745
S185
E
T
K
E
Y
F
Q
S
W
G
E
S
G
E
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8K0C4
503
56757
S185
E
A
K
E
Y
F
Q
S
W
G
E
S
G
E
R
Rat
Rattus norvegicus
Q64654
503
56688
S185
E
A
K
E
Y
F
K
S
W
G
E
S
G
E
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517490
563
61243
A216
P
F
L
G
H
A
V
A
F
G
R
S
P
I
E
Chicken
Gallus gallus
Q9PUB4
492
55246
Y177
A
G
P
C
L
L
V
Y
P
E
V
K
R
L
M
Frog
Xenopus laevis
NP_001091285
501
56963
R183
E
T
Q
E
Y
F
E
R
W
G
D
S
G
V
R
Zebra Danio
Brachydanio rerio
NP_001001730
499
56983
R177
E
T
K
D
Y
F
R
R
W
G
E
S
G
E
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P33269
512
58673
M192
D
T
I
C
E
T
A
M
G
V
S
I
N
A
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001001906
496
56226
R176
E
T
R
E
Y
F
N
R
W
G
D
S
G
E
K
Poplar Tree
Populus trichocarpa
XP_002299356
488
55530
I179
Y
E
L
E
H
L
I
I
L
T
A
S
R
C
L
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LTM7
502
57706
S179
S
L
F
W
L
A
A
S
I
L
F
R
I
A
F
Baker's Yeast
Sacchar. cerevisiae
P10614
530
60702
N187
D
S
K
N
F
R
L
N
E
R
T
T
G
T
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98
N.A.
96.6
N.A.
91.2
93.4
N.A.
58
23.6
80.3
75.9
N.A.
20.7
N.A.
N.A.
66.8
Protein Similarity:
100
98.6
N.A.
98.6
N.A.
96.6
97.4
N.A.
65.5
42.5
89.4
86.6
N.A.
40.6
N.A.
N.A.
81.3
P-Site Identity:
100
93.3
N.A.
93.3
N.A.
80
80
N.A.
13.3
0
66.6
73.3
N.A.
6.6
N.A.
N.A.
73.3
P-Site Similarity:
100
100
N.A.
100
N.A.
93.3
93.3
N.A.
40
0
86.6
86.6
N.A.
20
N.A.
N.A.
86.6
Percent
Protein Identity:
37.9
N.A.
N.A.
20.4
35
N.A.
Protein Similarity:
56.4
N.A.
N.A.
37.3
54.9
N.A.
P-Site Identity:
13.3
N.A.
N.A.
6.6
13.3
N.A.
P-Site Similarity:
20
N.A.
N.A.
6.6
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
15
0
0
0
15
15
8
0
0
8
0
0
15
0
% A
% Cys:
0
0
0
15
0
0
0
0
0
0
0
0
0
8
0
% C
% Asp:
15
0
0
8
0
0
0
0
0
0
15
0
0
0
0
% D
% Glu:
58
8
0
58
8
0
15
0
8
8
43
0
0
50
8
% E
% Phe:
0
8
8
0
8
58
0
0
8
0
8
0
0
0
8
% F
% Gly:
0
8
0
8
0
0
0
0
8
65
0
0
65
0
0
% G
% His:
0
0
0
0
15
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
8
0
0
0
8
8
8
0
0
8
8
8
8
% I
% Lys:
0
0
50
0
0
0
8
0
0
0
0
8
0
0
29
% K
% Leu:
0
8
15
0
15
15
8
0
8
8
0
0
0
8
8
% L
% Met:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
8
% M
% Asn:
0
0
0
8
0
0
8
8
0
0
0
0
8
0
0
% N
% Pro:
8
0
8
0
0
0
0
0
8
0
0
0
8
0
0
% P
% Gln:
0
0
8
0
0
0
22
0
0
0
0
0
0
0
8
% Q
% Arg:
0
0
8
0
0
8
8
22
0
8
8
8
15
0
29
% R
% Ser:
8
8
0
0
0
0
0
43
0
0
8
72
0
0
0
% S
% Thr:
0
50
0
0
0
8
0
0
0
8
8
8
0
8
0
% T
% Val:
0
0
0
0
0
0
15
0
0
8
8
0
0
8
0
% V
% Trp:
0
0
0
8
0
0
0
0
58
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
58
0
0
8
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _