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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CYP51A1
All Species:
31.82
Human Site:
Y393
Identified Species:
53.85
UniProt:
Q16850
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16850
NP_000777.1
503
56806
Y393
T
P
Q
T
V
A
G
Y
T
I
P
P
G
H
Q
Chimpanzee
Pan troglodytes
XP_519193
509
57278
Y399
T
P
Q
T
V
A
G
Y
T
I
P
P
G
H
Q
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532457
503
56745
Y393
T
P
Q
T
I
A
G
Y
T
I
P
P
G
H
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q8K0C4
503
56757
Y393
T
P
Q
T
V
A
G
Y
T
I
P
P
G
H
Q
Rat
Rattus norvegicus
Q64654
503
56688
Y393
T
P
Q
T
V
A
G
Y
T
I
P
P
G
H
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517490
563
61243
R434
D
A
S
Y
K
D
G
R
P
L
T
D
D
E
V
Chicken
Gallus gallus
Q9PUB4
492
55246
Y381
K
T
L
E
L
N
G
Y
Q
I
P
K
G
W
N
Frog
Xenopus laevis
NP_001091285
501
56963
Y391
T
P
Q
S
V
A
G
Y
N
I
P
P
G
H
Q
Zebra Danio
Brachydanio rerio
NP_001001730
499
56983
Y385
T
P
Q
K
V
G
E
Y
T
I
P
P
G
H
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P33269
512
58673
K399
E
D
C
E
I
N
G
K
L
I
P
A
G
T
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001001906
496
56226
M383
S
P
L
T
Y
K
D
M
T
I
P
A
G
H
Q
Poplar Tree
Populus trichocarpa
XP_002299356
488
55530
V381
D
I
P
K
G
H
I
V
A
T
S
P
A
F
A
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LTM7
502
57706
Y387
T
H
I
K
V
Q
G
Y
D
I
P
P
K
R
R
Baker's Yeast
Sacchar. cerevisiae
P10614
530
60702
Y398
M
H
V
P
N
T
S
Y
V
I
P
A
G
Y
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98
N.A.
96.6
N.A.
91.2
93.4
N.A.
58
23.6
80.3
75.9
N.A.
20.7
N.A.
N.A.
66.8
Protein Similarity:
100
98.6
N.A.
98.6
N.A.
96.6
97.4
N.A.
65.5
42.5
89.4
86.6
N.A.
40.6
N.A.
N.A.
81.3
P-Site Identity:
100
100
N.A.
93.3
N.A.
100
100
N.A.
6.6
33.3
86.6
80
N.A.
26.6
N.A.
N.A.
53.3
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
13.3
40
93.3
80
N.A.
33.3
N.A.
N.A.
60
Percent
Protein Identity:
37.9
N.A.
N.A.
20.4
35
N.A.
Protein Similarity:
56.4
N.A.
N.A.
37.3
54.9
N.A.
P-Site Identity:
6.6
N.A.
N.A.
46.6
26.6
N.A.
P-Site Similarity:
6.6
N.A.
N.A.
53.3
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
43
0
0
8
0
0
22
8
0
8
% A
% Cys:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
15
8
0
0
0
8
8
0
8
0
0
8
8
0
0
% D
% Glu:
8
0
0
15
0
0
8
0
0
0
0
0
0
8
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% F
% Gly:
0
0
0
0
8
8
72
0
0
0
0
0
79
0
0
% G
% His:
0
15
0
0
0
8
0
0
0
0
0
0
0
58
8
% H
% Ile:
0
8
8
0
15
0
8
0
0
86
0
0
0
0
0
% I
% Lys:
8
0
0
22
8
8
0
8
0
0
0
8
8
0
0
% K
% Leu:
0
0
15
0
8
0
0
0
8
8
0
0
0
0
0
% L
% Met:
8
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
8
15
0
0
8
0
0
0
0
0
15
% N
% Pro:
0
58
8
8
0
0
0
0
8
0
86
65
0
0
0
% P
% Gln:
0
0
50
0
0
8
0
0
8
0
0
0
0
0
58
% Q
% Arg:
0
0
0
0
0
0
0
8
0
0
0
0
0
8
8
% R
% Ser:
8
0
8
8
0
0
8
0
0
0
8
0
0
0
0
% S
% Thr:
58
8
0
43
0
8
0
0
50
8
8
0
0
8
0
% T
% Val:
0
0
8
0
50
0
0
8
8
0
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% W
% Tyr:
0
0
0
8
8
0
0
72
0
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _