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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CYP51A1
All Species:
27.58
Human Site:
Y478
Identified Species:
46.67
UniProt:
Q16850
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16850
NP_000777.1
503
56806
Y478
E
F
D
L
I
D
G
Y
F
P
T
V
N
Y
T
Chimpanzee
Pan troglodytes
XP_519193
509
57278
Y484
E
F
D
L
I
D
G
Y
F
P
T
V
N
Y
T
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532457
503
56745
Y478
E
F
D
L
I
D
G
Y
F
P
T
V
N
Y
T
Cat
Felis silvestris
Mouse
Mus musculus
Q8K0C4
503
56757
Y478
E
F
D
L
I
N
G
Y
F
P
T
V
N
Y
T
Rat
Rattus norvegicus
Q64654
503
56688
Y478
E
F
D
L
I
N
G
Y
F
P
S
V
N
Y
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517490
563
61243
A524
I
M
T
M
M
R
M
A
R
T
T
Q
V
S
A
Chicken
Gallus gallus
Q9PUB4
492
55246
P466
D
W
Q
L
L
N
G
P
P
T
M
K
T
G
P
Frog
Xenopus laevis
NP_001091285
501
56963
Y476
E
F
E
L
V
D
G
Y
F
P
T
I
N
Y
T
Zebra Danio
Brachydanio rerio
NP_001001730
499
56983
H470
D
F
E
L
V
D
G
H
F
P
P
V
N
Y
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P33269
512
58673
S485
E
V
D
F
V
G
D
S
S
E
P
P
V
L
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001001906
496
56226
Y469
E
F
E
L
V
D
G
Y
F
P
G
I
N
Y
Q
Poplar Tree
Populus trichocarpa
XP_002299356
488
55530
D464
I
S
P
F
P
E
I
D
W
N
A
M
V
V
G
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LTM7
502
57706
M473
D
W
R
A
P
D
G
M
T
H
K
D
I
D
T
Baker's Yeast
Sacchar. cerevisiae
P10614
530
60702
K499
K
W
H
Y
P
E
G
K
T
V
P
P
P
D
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98
N.A.
96.6
N.A.
91.2
93.4
N.A.
58
23.6
80.3
75.9
N.A.
20.7
N.A.
N.A.
66.8
Protein Similarity:
100
98.6
N.A.
98.6
N.A.
96.6
97.4
N.A.
65.5
42.5
89.4
86.6
N.A.
40.6
N.A.
N.A.
81.3
P-Site Identity:
100
100
N.A.
100
N.A.
93.3
86.6
N.A.
6.6
13.3
80
66.6
N.A.
13.3
N.A.
N.A.
66.6
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
20
40
100
93.3
N.A.
20
N.A.
N.A.
86.6
Percent
Protein Identity:
37.9
N.A.
N.A.
20.4
35
N.A.
Protein Similarity:
56.4
N.A.
N.A.
37.3
54.9
N.A.
P-Site Identity:
0
N.A.
N.A.
20
6.6
N.A.
P-Site Similarity:
20
N.A.
N.A.
33.3
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
0
0
8
0
0
8
0
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
22
0
43
0
0
50
8
8
0
0
0
8
0
15
0
% D
% Glu:
58
0
22
0
0
15
0
0
0
8
0
0
0
0
0
% E
% Phe:
0
58
0
15
0
0
0
0
58
0
0
0
0
0
8
% F
% Gly:
0
0
0
0
0
8
79
0
0
0
8
0
0
8
8
% G
% His:
0
0
8
0
0
0
0
8
0
8
0
0
0
0
0
% H
% Ile:
15
0
0
0
36
0
8
0
0
0
0
15
8
0
8
% I
% Lys:
8
0
0
0
0
0
0
8
0
0
8
8
0
0
0
% K
% Leu:
0
0
0
65
8
0
0
0
0
0
0
0
0
8
0
% L
% Met:
0
8
0
8
8
0
8
8
0
0
8
8
0
0
0
% M
% Asn:
0
0
0
0
0
22
0
0
0
8
0
0
58
0
0
% N
% Pro:
0
0
8
0
22
0
0
8
8
58
22
15
8
0
8
% P
% Gln:
0
0
8
0
0
0
0
0
0
0
0
8
0
0
8
% Q
% Arg:
0
0
8
0
0
8
0
0
8
0
0
0
0
0
0
% R
% Ser:
0
8
0
0
0
0
0
8
8
0
8
0
0
8
0
% S
% Thr:
0
0
8
0
0
0
0
0
15
15
43
0
8
0
58
% T
% Val:
0
8
0
0
29
0
0
0
0
8
0
43
22
8
0
% V
% Trp:
0
22
0
0
0
0
0
0
8
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
50
0
0
0
0
0
58
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _