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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PFKFB3
All Species:
26.36
Human Site:
S172
Identified Species:
52.73
UniProt:
Q16875
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16875
NP_001138915.1
520
59609
S172
I
M
E
V
K
I
S
S
P
D
Y
K
D
C
N
Chimpanzee
Pan troglodytes
XP_001147864
523
59913
S172
I
M
E
V
K
I
S
S
P
D
Y
K
D
C
N
Rhesus Macaque
Macaca mulatta
XP_001107535
520
59589
S172
I
M
E
V
K
I
S
S
P
D
Y
K
D
C
N
Dog
Lupus familis
XP_544267
559
63551
S185
I
M
E
V
K
I
S
S
P
D
Y
K
D
C
N
Cat
Felis silvestris
Mouse
Mus musculus
P70265
519
59907
S178
I
L
E
V
K
V
S
S
P
D
Y
P
E
R
N
Rat
Rattus norvegicus
O35552
555
63657
S172
I
M
E
V
K
I
S
S
P
D
Y
K
D
C
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516067
579
65588
S238
V
M
E
V
K
L
S
S
P
D
Y
R
G
C
N
Chicken
Gallus gallus
Q91348
470
54386
E157
G
Y
K
V
L
F
V
E
S
I
C
D
D
P
A
Frog
Xenopus laevis
NP_001088535
470
54750
E157
P
F
K
A
F
F
I
E
S
I
C
D
D
P
D
Zebra Danio
Brachydanio rerio
NP_998562
536
62010
C175
I
L
E
V
K
V
S
C
P
D
Y
Q
D
C
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q21122
457
52072
R144
I
D
F
C
K
K
Q
R
L
R
C
F
F
I
E
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32604
452
52576
L139
S
W
S
N
D
H
E
L
I
I
N
N
A
K
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96.7
99.6
84.6
N.A.
65.5
89.9
N.A.
76.6
61.1
65.5
72.3
N.A.
N.A.
N.A.
47.1
N.A.
Protein Similarity:
100
97.1
99.8
87.6
N.A.
77.8
91.7
N.A.
84.2
77.1
76.7
84.1
N.A.
N.A.
N.A.
62.8
N.A.
P-Site Identity:
100
100
100
100
N.A.
66.6
100
N.A.
73.3
13.3
6.6
73.3
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
100
100
100
100
N.A.
86.6
100
N.A.
93.3
20
20
93.3
N.A.
N.A.
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
40.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
59.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
9
0
0
0
0
0
0
0
0
9
0
9
% A
% Cys:
0
0
0
9
0
0
0
9
0
0
25
0
0
59
0
% C
% Asp:
0
9
0
0
9
0
0
0
0
67
0
17
67
0
17
% D
% Glu:
0
0
67
0
0
0
9
17
0
0
0
0
9
0
9
% E
% Phe:
0
9
9
0
9
17
0
0
0
0
0
9
9
0
0
% F
% Gly:
9
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% G
% His:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% H
% Ile:
67
0
0
0
0
42
9
0
9
25
0
0
0
9
0
% I
% Lys:
0
0
17
0
75
9
0
0
0
0
0
42
0
9
0
% K
% Leu:
0
17
0
0
9
9
0
9
9
0
0
0
0
0
0
% L
% Met:
0
50
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
9
0
0
0
0
0
0
9
9
0
0
67
% N
% Pro:
9
0
0
0
0
0
0
0
67
0
0
9
0
17
0
% P
% Gln:
0
0
0
0
0
0
9
0
0
0
0
9
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
9
0
9
0
9
0
9
0
% R
% Ser:
9
0
9
0
0
0
67
59
17
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
9
0
0
75
0
17
9
0
0
0
0
0
0
0
0
% V
% Trp:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
9
0
0
0
0
0
0
0
0
67
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _