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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PFKFB3
All Species:
4.55
Human Site:
S512
Identified Species:
9.09
UniProt:
Q16875
Number Species:
11
Phosphosite Substitution
Charge Score:
0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16875
NP_001138915.1
520
59609
S512
Q
N
M
K
G
S
R
S
S
A
D
S
S
R
K
Chimpanzee
Pan troglodytes
XP_001147864
523
59913
C512
Q
P
L
L
G
Q
A
C
L
N
W
K
G
V
M
Rhesus Macaque
Macaca mulatta
XP_001107535
520
59589
S512
Q
N
M
K
G
S
R
S
S
A
D
S
S
R
K
Dog
Lupus familis
XP_544267
559
63551
E525
K
P
R
I
N
S
F
E
E
H
V
A
S
T
S
Cat
Felis silvestris
Mouse
Mus musculus
P70265
519
59907
K511
Q
E
G
A
D
Q
P
K
T
Q
V
S
I
P
V
Rat
Rattus norvegicus
O35552
555
63657
V512
I
N
S
F
E
E
H
V
A
S
T
S
A
A
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516067
579
65588
Q571
V
P
T
Q
L
A
G
Q
P
L
L
G
K
A
C
Chicken
Gallus gallus
Q91348
470
54386
L463
S
R
P
P
A
E
A
L
V
T
V
P
E
H
Y
Frog
Xenopus laevis
NP_001088535
470
54750
L463
S
R
E
P
D
E
A
L
D
T
V
P
E
H
F
Zebra Danio
Brachydanio rerio
NP_998562
536
62010
E515
S
T
Q
N
W
L
S
E
A
C
L
R
S
F
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q21122
457
52072
P450
T
E
T
S
D
Q
L
P
L
C
D
S
P
R
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32604
452
52576
D445
K
L
H
Q
L
L
N
D
S
P
L
E
D
K
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96.7
99.6
84.6
N.A.
65.5
89.9
N.A.
76.6
61.1
65.5
72.3
N.A.
N.A.
N.A.
47.1
N.A.
Protein Similarity:
100
97.1
99.8
87.6
N.A.
77.8
91.7
N.A.
84.2
77.1
76.7
84.1
N.A.
N.A.
N.A.
62.8
N.A.
P-Site Identity:
100
13.3
100
13.3
N.A.
13.3
13.3
N.A.
0
0
0
6.6
N.A.
N.A.
N.A.
20
N.A.
P-Site Similarity:
100
20
100
26.6
N.A.
20
33.3
N.A.
13.3
0
0
13.3
N.A.
N.A.
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
40.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
59.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
9
9
9
25
0
17
17
0
9
9
17
0
% A
% Cys:
0
0
0
0
0
0
0
9
0
17
0
0
0
0
9
% C
% Asp:
0
0
0
0
25
0
0
9
9
0
25
0
9
0
9
% D
% Glu:
0
17
9
0
9
25
0
17
9
0
0
9
17
0
0
% E
% Phe:
0
0
0
9
0
0
9
0
0
0
0
0
0
9
17
% F
% Gly:
0
0
9
0
25
0
9
0
0
0
0
9
9
0
0
% G
% His:
0
0
9
0
0
0
9
0
0
9
0
0
0
17
0
% H
% Ile:
9
0
0
9
0
0
0
0
0
0
0
0
9
0
0
% I
% Lys:
17
0
0
17
0
0
0
9
0
0
0
9
9
9
17
% K
% Leu:
0
9
9
9
17
17
9
17
17
9
25
0
0
0
17
% L
% Met:
0
0
17
0
0
0
0
0
0
0
0
0
0
0
9
% M
% Asn:
0
25
0
9
9
0
9
0
0
9
0
0
0
0
0
% N
% Pro:
0
25
9
17
0
0
9
9
9
9
0
17
9
9
0
% P
% Gln:
34
0
9
17
0
25
0
9
0
9
0
0
0
0
0
% Q
% Arg:
0
17
9
0
0
0
17
0
0
0
0
9
0
25
0
% R
% Ser:
25
0
9
9
0
25
9
17
25
9
0
42
34
0
9
% S
% Thr:
9
9
17
0
0
0
0
0
9
17
9
0
0
9
0
% T
% Val:
9
0
0
0
0
0
0
9
9
0
34
0
0
9
9
% V
% Trp:
0
0
0
0
9
0
0
0
0
0
9
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _