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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PFKFB4
All Species:
30.3
Human Site:
S201
Identified Species:
60.61
UniProt:
Q16877
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16877
NP_004558.1
469
54040
S201
R
I
E
C
Y
E
N
S
Y
E
S
L
D
E
D
Chimpanzee
Pan troglodytes
XP_001158340
470
54094
Y202
I
E
C
Y
E
N
S
Y
E
P
L
S
T
F
S
Rhesus Macaque
Macaca mulatta
XP_001112503
469
54004
S201
R
I
E
C
Y
E
N
S
Y
E
S
L
D
E
D
Dog
Lupus familis
XP_541893
469
54201
S201
R
I
E
C
Y
E
N
S
Y
E
S
L
D
E
D
Cat
Felis silvestris
Mouse
Mus musculus
Q6DTY7
469
54048
S201
R
I
E
C
Y
E
N
S
Y
E
S
L
D
E
D
Rat
Rattus norvegicus
P25114
469
54136
S201
R
I
E
C
Y
E
N
S
Y
E
S
L
D
E
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509392
470
54778
T202
R
I
E
C
Y
Q
I
T
Y
Q
P
L
D
D
E
Chicken
Gallus gallus
Q91348
470
54386
T202
R
I
E
C
Y
K
A
T
Y
E
P
L
D
E
Q
Frog
Xenopus laevis
NP_001084943
470
54502
F202
R
I
D
S
Y
K
N
F
Y
E
T
L
D
E
K
Zebra Danio
Brachydanio rerio
NP_942111
469
54610
S201
R
I
K
C
Y
E
S
S
Y
Q
P
L
D
E
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q21122
457
52072
Q197
R
I
E
N
Y
K
K
Q
Y
E
P
L
D
E
S
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32604
452
52576
L180
Y
E
R
F
Y
E
P
L
D
P
Q
K
D
K
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
97
98.7
N.A.
97.4
97.2
N.A.
74
73.6
83.1
83.1
N.A.
N.A.
N.A.
47.1
N.A.
Protein Similarity:
100
98.9
98.7
99.3
N.A.
98.7
98.5
N.A.
84.8
83.8
90.6
90.8
N.A.
N.A.
N.A.
65
N.A.
P-Site Identity:
100
0
100
100
N.A.
100
93.3
N.A.
53.3
66.6
60
66.6
N.A.
N.A.
N.A.
60
N.A.
P-Site Similarity:
100
6.6
100
100
N.A.
100
100
N.A.
86.6
80
80
93.3
N.A.
N.A.
N.A.
66.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
44.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
62.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
9
67
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
9
0
0
0
0
0
9
0
0
0
92
9
42
% D
% Glu:
0
17
67
0
9
59
0
0
9
67
0
0
0
75
17
% E
% Phe:
0
0
0
9
0
0
0
9
0
0
0
0
0
9
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
9
84
0
0
0
0
9
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
9
0
0
25
9
0
0
0
0
9
0
9
9
% K
% Leu:
0
0
0
0
0
0
0
9
0
0
9
84
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
9
0
9
50
0
0
0
0
0
0
0
9
% N
% Pro:
0
0
0
0
0
0
9
0
0
17
34
0
0
0
0
% P
% Gln:
0
0
0
0
0
9
0
9
0
17
9
0
0
0
9
% Q
% Arg:
84
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
9
0
0
17
50
0
0
42
9
0
0
17
% S
% Thr:
0
0
0
0
0
0
0
17
0
0
9
0
9
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
0
0
9
92
0
0
9
84
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _