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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PFKFB4 All Species: 30.3
Human Site: S201 Identified Species: 60.61
UniProt: Q16877 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q16877 NP_004558.1 469 54040 S201 R I E C Y E N S Y E S L D E D
Chimpanzee Pan troglodytes XP_001158340 470 54094 Y202 I E C Y E N S Y E P L S T F S
Rhesus Macaque Macaca mulatta XP_001112503 469 54004 S201 R I E C Y E N S Y E S L D E D
Dog Lupus familis XP_541893 469 54201 S201 R I E C Y E N S Y E S L D E D
Cat Felis silvestris
Mouse Mus musculus Q6DTY7 469 54048 S201 R I E C Y E N S Y E S L D E D
Rat Rattus norvegicus P25114 469 54136 S201 R I E C Y E N S Y E S L D E E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509392 470 54778 T202 R I E C Y Q I T Y Q P L D D E
Chicken Gallus gallus Q91348 470 54386 T202 R I E C Y K A T Y E P L D E Q
Frog Xenopus laevis NP_001084943 470 54502 F202 R I D S Y K N F Y E T L D E K
Zebra Danio Brachydanio rerio NP_942111 469 54610 S201 R I K C Y E S S Y Q P L D E N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q21122 457 52072 Q197 R I E N Y K K Q Y E P L D E S
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P32604 452 52576 L180 Y E R F Y E P L D P Q K D K D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.9 97 98.7 N.A. 97.4 97.2 N.A. 74 73.6 83.1 83.1 N.A. N.A. N.A. 47.1 N.A.
Protein Similarity: 100 98.9 98.7 99.3 N.A. 98.7 98.5 N.A. 84.8 83.8 90.6 90.8 N.A. N.A. N.A. 65 N.A.
P-Site Identity: 100 0 100 100 N.A. 100 93.3 N.A. 53.3 66.6 60 66.6 N.A. N.A. N.A. 60 N.A.
P-Site Similarity: 100 6.6 100 100 N.A. 100 100 N.A. 86.6 80 80 93.3 N.A. N.A. N.A. 66.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 44.1 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 62.9 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 26.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 9 67 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 9 0 0 0 0 0 9 0 0 0 92 9 42 % D
% Glu: 0 17 67 0 9 59 0 0 9 67 0 0 0 75 17 % E
% Phe: 0 0 0 9 0 0 0 9 0 0 0 0 0 9 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 9 84 0 0 0 0 9 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 9 0 0 25 9 0 0 0 0 9 0 9 9 % K
% Leu: 0 0 0 0 0 0 0 9 0 0 9 84 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 9 0 9 50 0 0 0 0 0 0 0 9 % N
% Pro: 0 0 0 0 0 0 9 0 0 17 34 0 0 0 0 % P
% Gln: 0 0 0 0 0 9 0 9 0 17 9 0 0 0 9 % Q
% Arg: 84 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 9 0 0 17 50 0 0 42 9 0 0 17 % S
% Thr: 0 0 0 0 0 0 0 17 0 0 9 0 9 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 9 0 0 9 92 0 0 9 84 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _