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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PFKFB4
All Species:
36.06
Human Site:
S214
Identified Species:
72.12
UniProt:
Q16877
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16877
NP_004558.1
469
54040
S214
E
D
L
D
R
D
L
S
Y
I
K
I
M
D
V
Chimpanzee
Pan troglodytes
XP_001158340
470
54094
S215
F
S
L
D
R
D
L
S
Y
I
K
I
M
D
V
Rhesus Macaque
Macaca mulatta
XP_001112503
469
54004
L214
E
D
L
D
R
D
G
L
I
F
L
F
I
S
L
Dog
Lupus familis
XP_541893
469
54201
S214
E
D
L
D
R
D
L
S
Y
I
K
I
M
D
V
Cat
Felis silvestris
Mouse
Mus musculus
Q6DTY7
469
54048
S214
E
D
L
D
R
D
L
S
Y
I
K
I
M
D
V
Rat
Rattus norvegicus
P25114
469
54136
S214
E
E
Q
D
R
D
L
S
Y
I
K
I
M
D
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509392
470
54778
S215
D
E
L
D
S
S
L
S
Y
I
K
I
F
D
V
Chicken
Gallus gallus
Q91348
470
54386
S215
E
Q
L
D
S
G
L
S
Y
I
K
I
F
D
V
Frog
Xenopus laevis
NP_001084943
470
54502
S215
E
K
L
D
K
D
L
S
Y
I
K
I
M
D
V
Zebra Danio
Brachydanio rerio
NP_942111
469
54610
S214
E
N
L
D
R
E
L
S
Y
I
K
I
M
D
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q21122
457
52072
S210
E
S
E
D
E
S
L
S
F
I
K
V
I
N
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32604
452
52576
L193
K
D
M
T
F
I
K
L
V
N
I
I
E
E
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
97
98.7
N.A.
97.4
97.2
N.A.
74
73.6
83.1
83.1
N.A.
N.A.
N.A.
47.1
N.A.
Protein Similarity:
100
98.9
98.7
99.3
N.A.
98.7
98.5
N.A.
84.8
83.8
90.6
90.8
N.A.
N.A.
N.A.
65
N.A.
P-Site Identity:
100
86.6
40
100
N.A.
100
86.6
N.A.
66.6
73.3
86.6
86.6
N.A.
N.A.
N.A.
40
N.A.
P-Site Similarity:
100
86.6
53.3
100
N.A.
100
93.3
N.A.
80
73.3
93.3
100
N.A.
N.A.
N.A.
66.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
44.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
62.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
42
0
92
0
59
0
0
0
0
0
0
0
75
0
% D
% Glu:
75
17
9
0
9
9
0
0
0
0
0
0
9
9
0
% E
% Phe:
9
0
0
0
9
0
0
0
9
9
0
9
17
0
0
% F
% Gly:
0
0
0
0
0
9
9
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
9
0
0
9
84
9
84
17
0
0
% I
% Lys:
9
9
0
0
9
0
9
0
0
0
84
0
0
0
0
% K
% Leu:
0
0
75
0
0
0
84
17
0
0
9
0
0
0
9
% L
% Met:
0
0
9
0
0
0
0
0
0
0
0
0
59
0
0
% M
% Asn:
0
9
0
0
0
0
0
0
0
9
0
0
0
9
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
9
9
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
59
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
17
0
0
17
17
0
84
0
0
0
0
0
9
0
% S
% Thr:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
9
0
0
9
0
0
84
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
75
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _