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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PFKFB4
All Species:
16.97
Human Site:
S284
Identified Species:
33.94
UniProt:
Q16877
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16877
NP_004558.1
469
54040
S284
R
G
R
E
F
A
K
S
L
A
Q
F
I
S
D
Chimpanzee
Pan troglodytes
XP_001158340
470
54094
S285
R
G
R
E
F
A
K
S
L
A
Q
F
I
S
D
Rhesus Macaque
Macaca mulatta
XP_001112503
469
54004
S284
R
G
R
E
F
A
K
S
L
A
Q
F
I
S
D
Dog
Lupus familis
XP_541893
469
54201
S284
R
G
R
E
F
A
K
S
L
A
Q
F
I
R
D
Cat
Felis silvestris
Mouse
Mus musculus
Q6DTY7
469
54048
H284
R
G
R
E
F
S
K
H
L
A
Q
F
I
S
D
Rat
Rattus norvegicus
P25114
469
54136
H284
R
G
R
E
F
S
K
H
L
A
Q
F
I
S
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509392
470
54778
A285
R
G
K
Q
Y
A
Y
A
L
A
N
F
I
Q
S
Chicken
Gallus gallus
Q91348
470
54386
A285
R
G
R
Q
Y
A
Q
A
L
A
E
F
I
R
S
Frog
Xenopus laevis
NP_001084943
470
54502
C285
R
G
K
E
F
A
K
C
L
G
S
Y
I
R
E
Zebra Danio
Brachydanio rerio
NP_942111
469
54610
S284
R
G
K
E
F
A
H
S
L
G
R
F
I
Q
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q21122
457
52072
A280
D
G
Q
K
Y
A
S
A
L
A
D
F
F
E
E
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32604
452
52576
L263
Y
A
K
K
L
E
Q
L
V
K
E
S
A
G
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
97
98.7
N.A.
97.4
97.2
N.A.
74
73.6
83.1
83.1
N.A.
N.A.
N.A.
47.1
N.A.
Protein Similarity:
100
98.9
98.7
99.3
N.A.
98.7
98.5
N.A.
84.8
83.8
90.6
90.8
N.A.
N.A.
N.A.
65
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
86.6
86.6
N.A.
46.6
53.3
53.3
66.6
N.A.
N.A.
N.A.
33.3
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
73.3
86.6
73.3
80
N.A.
N.A.
N.A.
66.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
44.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
62.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
0
0
75
0
25
0
75
0
0
9
0
0
% A
% Cys:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% C
% Asp:
9
0
0
0
0
0
0
0
0
0
9
0
0
0
59
% D
% Glu:
0
0
0
67
0
9
0
0
0
0
17
0
0
9
25
% E
% Phe:
0
0
0
0
67
0
0
0
0
0
0
84
9
0
0
% F
% Gly:
0
92
0
0
0
0
0
0
0
17
0
0
0
9
0
% G
% His:
0
0
0
0
0
0
9
17
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
84
0
0
% I
% Lys:
0
0
34
17
0
0
59
0
0
9
0
0
0
0
0
% K
% Leu:
0
0
0
0
9
0
0
9
92
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
9
17
0
0
17
0
0
0
50
0
0
17
0
% Q
% Arg:
84
0
59
0
0
0
0
0
0
0
9
0
0
25
0
% R
% Ser:
0
0
0
0
0
17
9
42
0
0
9
9
0
42
17
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
0
0
0
25
0
9
0
0
0
0
9
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _