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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PFKFB4
All Species:
22.73
Human Site:
Y19
Identified Species:
45.45
UniProt:
Q16877
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16877
NP_004558.1
469
54040
Y19
L
K
K
I
W
M
P
Y
S
N
G
R
P
A
L
Chimpanzee
Pan troglodytes
XP_001158340
470
54094
Y19
L
K
K
I
W
M
P
Y
S
N
G
R
P
A
L
Rhesus Macaque
Macaca mulatta
XP_001112503
469
54004
Y19
L
K
K
I
W
M
P
Y
S
N
G
R
P
A
L
Dog
Lupus familis
XP_541893
469
54201
Y19
L
K
K
I
W
M
P
Y
S
N
G
R
P
A
L
Cat
Felis silvestris
Mouse
Mus musculus
Q6DTY7
469
54048
Y19
L
K
K
I
W
M
P
Y
S
N
G
R
P
A
L
Rat
Rattus norvegicus
P25114
469
54136
Y19
L
K
K
I
W
M
P
Y
S
N
G
R
P
A
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509392
470
54778
H20
L
Q
K
I
W
I
P
H
T
S
N
R
L
Q
Q
Chicken
Gallus gallus
Q91348
470
54386
L21
L
Q
K
V
W
V
P
L
S
L
H
R
L
R
R
Frog
Xenopus laevis
NP_001084943
470
54502
F20
L
K
K
I
W
V
P
F
N
N
G
H
P
V
Q
Zebra Danio
Brachydanio rerio
NP_942111
469
54610
C19
L
R
K
I
W
M
P
C
K
N
G
L
P
E
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q21122
457
52072
G21
V
A
H
S
D
E
H
G
F
S
D
Q
V
R
V
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32604
452
52576
V19
I
K
V
C
V
I
M
V
G
L
P
A
R
G
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
97
98.7
N.A.
97.4
97.2
N.A.
74
73.6
83.1
83.1
N.A.
N.A.
N.A.
47.1
N.A.
Protein Similarity:
100
98.9
98.7
99.3
N.A.
98.7
98.5
N.A.
84.8
83.8
90.6
90.8
N.A.
N.A.
N.A.
65
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
40
40
60
60
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
73.3
60
80
66.6
N.A.
N.A.
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
44.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
62.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
0
0
0
0
0
0
0
0
9
0
50
0
% A
% Cys:
0
0
0
9
0
0
0
9
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
9
0
0
0
0
0
9
0
0
0
0
% D
% Glu:
0
0
0
0
0
9
0
0
0
0
0
0
0
9
0
% E
% Phe:
0
0
0
0
0
0
0
9
9
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
9
9
0
67
0
0
9
0
% G
% His:
0
0
9
0
0
0
9
9
0
0
9
9
0
0
0
% H
% Ile:
9
0
0
75
0
17
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
67
84
0
0
0
0
0
9
0
0
0
0
0
17
% K
% Leu:
84
0
0
0
0
0
0
9
0
17
0
9
17
0
50
% L
% Met:
0
0
0
0
0
59
9
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
9
67
9
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
84
0
0
0
9
0
67
0
0
% P
% Gln:
0
17
0
0
0
0
0
0
0
0
0
9
0
9
17
% Q
% Arg:
0
9
0
0
0
0
0
0
0
0
0
67
9
17
9
% R
% Ser:
0
0
0
9
0
0
0
0
59
17
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% T
% Val:
9
0
9
9
9
17
0
9
0
0
0
0
9
9
9
% V
% Trp:
0
0
0
0
84
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
50
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _