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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PFKFB4
All Species:
34.24
Human Site:
Y86
Identified Species:
68.48
UniProt:
Q16877
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16877
NP_004558.1
469
54040
Y86
R
R
D
V
V
K
T
Y
K
S
F
E
F
F
L
Chimpanzee
Pan troglodytes
XP_001158340
470
54094
Y86
R
R
D
V
V
K
T
Y
K
S
F
E
F
F
L
Rhesus Macaque
Macaca mulatta
XP_001112503
469
54004
Y86
R
R
N
M
V
K
T
Y
K
S
F
E
F
F
L
Dog
Lupus familis
XP_541893
469
54201
Y86
R
R
E
M
V
K
T
Y
K
S
F
E
F
F
L
Cat
Felis silvestris
Mouse
Mus musculus
Q6DTY7
469
54048
Y86
R
R
D
I
V
K
T
Y
K
S
F
E
F
F
L
Rat
Rattus norvegicus
P25114
469
54136
Y86
R
R
D
M
V
K
T
Y
K
S
F
E
F
F
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509392
470
54778
Y87
R
R
E
A
V
Q
S
Y
K
N
Y
E
F
F
R
Chicken
Gallus gallus
Q91348
470
54386
Y87
R
R
E
A
V
Q
S
Y
K
N
Y
E
F
F
R
Frog
Xenopus laevis
NP_001084943
470
54502
F87
R
R
D
L
V
Q
T
F
K
S
F
E
F
F
L
Zebra Danio
Brachydanio rerio
NP_942111
469
54610
Y86
R
R
E
C
V
K
I
Y
K
S
F
E
F
F
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q21122
457
52072
L95
S
P
N
N
A
D
A
L
K
V
R
A
E
S
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32604
452
52576
A85
R
E
L
A
A
Q
N
A
I
K
D
I
V
N
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
97
98.7
N.A.
97.4
97.2
N.A.
74
73.6
83.1
83.1
N.A.
N.A.
N.A.
47.1
N.A.
Protein Similarity:
100
98.9
98.7
99.3
N.A.
98.7
98.5
N.A.
84.8
83.8
90.6
90.8
N.A.
N.A.
N.A.
65
N.A.
P-Site Identity:
100
100
86.6
86.6
N.A.
93.3
93.3
N.A.
53.3
53.3
80
73.3
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
86.6
86.6
100
80
N.A.
N.A.
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
44.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
62.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
25
17
0
9
9
0
0
0
9
0
0
9
% A
% Cys:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
42
0
0
9
0
0
0
0
9
0
0
0
0
% D
% Glu:
0
9
34
0
0
0
0
0
0
0
0
84
9
0
0
% E
% Phe:
0
0
0
0
0
0
0
9
0
0
67
0
84
84
9
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
9
0
0
9
0
9
0
0
9
0
0
0
% I
% Lys:
0
0
0
0
0
59
0
0
92
9
0
0
0
0
0
% K
% Leu:
0
0
9
9
0
0
0
9
0
0
0
0
0
0
59
% L
% Met:
0
0
0
25
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
17
9
0
0
9
0
0
17
0
0
0
9
0
% N
% Pro:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
34
0
0
0
0
0
0
0
0
0
% Q
% Arg:
92
84
0
0
0
0
0
0
0
0
9
0
0
0
25
% R
% Ser:
9
0
0
0
0
0
17
0
0
67
0
0
0
9
0
% S
% Thr:
0
0
0
0
0
0
59
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
17
84
0
0
0
0
9
0
0
9
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
75
0
0
17
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _