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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TXNRD1 All Species: 10.61
Human Site: S233 Identified Species: 16.67
UniProt: Q16881 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.21
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q16881 NP_001087240.1 649 70906 S233 L G Q A L Q D S R N Y G W K V
Chimpanzee Pan troglodytes NP_001116141 499 54568 R121 W G Y R V A L R E K K V V Y E
Rhesus Macaque Macaca mulatta NP_001152971 524 56314 V145 S L N W G H R V Q L Q D R K V
Dog Lupus familis XP_850181 509 55065 R131 K S L N W G H R V Q L Q D R K
Cat Felis silvestris
Mouse Mus musculus Q9JMH6 613 66915 S225 S V Q S H I G S L N W G Y R V
Rat Rattus norvegicus O89049 498 54218 L120 N W G Y R V A L R E K K V V Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507796 621 68478 Y210 A L Q D S R K Y G W Q V E E T
Chicken Gallus gallus NP_001116249 606 66439 S218 A V Q N Y I G S L N W G Y R L
Frog Xenopus laevis NP_001087660 596 65709 S210 A I Q N Y I G S L N W G Y R V
Zebra Danio Brachydanio rerio NP_898895 602 65949 S214 A V N N Y I G S L N W G Y R V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P91938 596 64304 H211 L V Q S V Q N H I K S V N W V
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q17745 667 74094 A243 L G H S I H D A K K Y G W K L
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P42770 565 60834 R187 N K N A E L Q R L T G I Y K N
Baker's Yeast Sacchar. cerevisiae P41921 483 53422 W105 K E H L T F N W P E F K Q K R
Red Bread Mold Neurospora crassa Q873E8 468 50294 Q90 F D W P T F K Q K R D A Y V A
Conservation
Percent
Protein Identity: 100 76.5 46.5 44.3 N.A. 74.4 70.1 N.A. 72.1 66.5 64.5 64 N.A. 45.9 N.A. 47.8 N.A.
Protein Similarity: 100 76.7 57.9 56.3 N.A. 80.7 73.9 N.A. 82.1 78.4 77.8 77.1 N.A. 59 N.A. 62.9 N.A.
P-Site Identity: 100 6.6 13.3 0 N.A. 33.3 6.6 N.A. 6.6 26.6 33.3 26.6 N.A. 26.6 N.A. 46.6 N.A.
P-Site Similarity: 100 13.3 20 6.6 N.A. 60 6.6 N.A. 20 53.3 53.3 46.6 N.A. 46.6 N.A. 80 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 33.4 27.7 26.5
Protein Similarity: N.A. N.A. N.A. 49.9 44.2 41.6
P-Site Identity: N.A. N.A. N.A. 13.3 6.6 0
P-Site Similarity: N.A. N.A. N.A. 20 20 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 27 0 0 14 0 7 7 7 0 0 0 7 0 0 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 7 0 7 0 0 14 0 0 0 7 7 7 0 0 % D
% Glu: 0 7 0 0 7 0 0 0 7 14 0 0 7 7 7 % E
% Phe: 7 0 0 0 0 14 0 0 0 0 7 0 0 0 0 % F
% Gly: 0 20 7 0 7 7 27 0 7 0 7 40 0 0 0 % G
% His: 0 0 14 0 7 14 7 7 0 0 0 0 0 0 0 % H
% Ile: 0 7 0 0 7 27 0 0 7 0 0 7 0 0 0 % I
% Lys: 14 7 0 0 0 0 14 0 14 20 14 14 0 34 7 % K
% Leu: 20 14 7 7 7 7 7 7 34 7 7 0 0 0 14 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 14 0 20 27 0 0 14 0 0 34 0 0 7 0 7 % N
% Pro: 0 0 0 7 0 0 0 0 7 0 0 0 0 0 0 % P
% Gln: 0 0 40 0 0 14 7 7 7 7 14 7 7 0 0 % Q
% Arg: 0 0 0 7 7 7 7 20 14 7 0 0 7 34 7 % R
% Ser: 14 7 0 20 7 0 0 34 0 0 7 0 0 0 0 % S
% Thr: 0 0 0 0 14 0 0 0 0 7 0 0 0 0 7 % T
% Val: 0 27 0 0 14 7 0 7 7 0 0 20 14 14 40 % V
% Trp: 7 7 7 7 7 0 0 7 0 7 27 0 14 7 0 % W
% Tyr: 0 0 7 7 20 0 0 7 0 0 14 0 40 7 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _