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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TXNRD1 All Species: 19.7
Human Site: S511 Identified Species: 30.95
UniProt: Q16881 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q16881 NP_001087240.1 649 70906 S511 A Q R L Y A G S T V K C D Y E
Chimpanzee Pan troglodytes NP_001116141 499 54568 E368 S T V K C D Y E N V P T T V F
Rhesus Macaque Macaca mulatta NP_001152971 524 56314 Y392 G S S D L M D Y D N V P T T V
Dog Lupus familis XP_850181 509 55065 D378 G Q A S D V M D Y D N V P T T
Cat Felis silvestris
Mouse Mus musculus Q9JMH6 613 66915 S475 A Q R L Y G G S N V K C D Y D
Rat Rattus norvegicus O89049 498 54218 Y367 G S T V K C D Y D N V P T T V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507796 621 68478 S485 A R R L Y S G S T V K C D Y D
Chicken Gallus gallus NP_001116249 606 66439 S468 A R R L Y G G S S T K C D Y I
Frog Xenopus laevis NP_001087660 596 65709 S460 A R R L Y R G S K V K C D Y I
Zebra Danio Brachydanio rerio NP_898895 602 65949 A464 A R R L Y A G A T M K C D Y V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P91938 596 64304 S458 A R R L Y G G S T Q R M D Y K
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q17745 667 74094 A527 M R R I F D G A N E L T E Y D
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P42770 565 60834 A434 D Y R A V P C A V F S Q P P I
Baker's Yeast Sacchar. cerevisiae P41921 483 53422 L352 A I A A G R K L S N R L F G P
Red Bread Mold Neurospora crassa Q873E8 468 50294 A337 A A G R K L A A R L F G P E E
Conservation
Percent
Protein Identity: 100 76.5 46.5 44.3 N.A. 74.4 70.1 N.A. 72.1 66.5 64.5 64 N.A. 45.9 N.A. 47.8 N.A.
Protein Similarity: 100 76.7 57.9 56.3 N.A. 80.7 73.9 N.A. 82.1 78.4 77.8 77.1 N.A. 59 N.A. 62.9 N.A.
P-Site Identity: 100 6.6 0 6.6 N.A. 80 0 N.A. 80 66.6 73.3 73.3 N.A. 60 N.A. 20 N.A.
P-Site Similarity: 100 13.3 0 6.6 N.A. 86.6 6.6 N.A. 100 80 80 93.3 N.A. 80 N.A. 60 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 33.4 27.7 26.5
Protein Similarity: N.A. N.A. N.A. 49.9 44.2 41.6
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 13.3
P-Site Similarity: N.A. N.A. N.A. 13.3 20 26.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 60 7 14 14 0 14 7 27 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 7 7 7 0 0 0 0 40 0 0 0 % C
% Asp: 7 0 0 7 7 14 14 7 14 7 0 0 47 0 20 % D
% Glu: 0 0 0 0 0 0 0 7 0 7 0 0 7 7 14 % E
% Phe: 0 0 0 0 7 0 0 0 0 7 7 0 7 0 7 % F
% Gly: 20 0 7 0 7 20 54 0 0 0 0 7 0 7 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 7 0 7 0 0 0 0 0 0 0 0 0 0 20 % I
% Lys: 0 0 0 7 14 0 7 0 7 0 40 0 0 0 7 % K
% Leu: 0 0 0 47 7 7 0 7 0 7 7 7 0 0 0 % L
% Met: 7 0 0 0 0 7 7 0 0 7 0 7 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 20 20 7 0 0 0 0 % N
% Pro: 0 0 0 0 0 7 0 0 0 0 7 14 20 7 7 % P
% Gln: 0 20 0 0 0 0 0 0 0 7 0 7 0 0 0 % Q
% Arg: 0 40 60 7 0 14 0 0 7 0 14 0 0 0 0 % R
% Ser: 7 14 7 7 0 7 0 40 14 0 7 0 0 0 0 % S
% Thr: 0 7 7 0 0 0 0 0 27 7 0 14 20 20 7 % T
% Val: 0 0 7 7 7 7 0 0 7 34 14 7 0 7 20 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 7 0 0 47 0 7 14 7 0 0 0 0 54 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _