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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TXNRD1
All Species:
10.91
Human Site:
Y277
Identified Species:
17.14
UniProt:
Q16881
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16881
NP_001087240.1
649
70906
Y277
L
R
E
K
K
V
V
Y
E
N
A
Y
G
Q
F
Chimpanzee
Pan troglodytes
NP_001116141
499
54568
G162
E
R
F
L
I
A
T
G
E
R
P
R
Y
L
G
Rhesus Macaque
Macaca mulatta
NP_001152971
524
56314
I186
L
S
A
D
H
I
I
I
A
T
G
G
R
P
R
Dog
Lupus familis
XP_850181
509
55065
V172
L
L
S
A
E
H
I
V
I
A
T
G
G
R
P
Cat
Felis silvestris
Mouse
Mus musculus
Q9JMH6
613
66915
Y266
N
K
G
K
E
K
I
Y
S
A
E
R
F
L
I
Rat
Rattus norvegicus
O89049
498
54218
T161
A
E
R
F
L
I
A
T
G
E
R
P
R
Y
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507796
621
68478
Y251
L
R
E
N
K
V
T
Y
E
N
A
Y
G
E
F
Chicken
Gallus gallus
NP_001116249
606
66439
H259
R
K
G
Q
V
T
Y
H
T
A
E
T
F
V
L
Frog
Xenopus laevis
NP_001087660
596
65709
F251
K
K
G
K
E
S
F
F
T
A
E
K
F
V
V
Zebra Danio
Brachydanio rerio
NP_898895
602
65949
Y255
K
R
G
K
E
T
F
Y
T
A
A
Q
F
V
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P91938
596
64304
R252
A
K
L
K
S
G
E
R
T
I
T
A
Q
T
F
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q17745
667
74094
Y288
L
R
E
K
T
V
T
Y
I
N
S
Y
G
E
F
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42770
565
60834
I228
K
I
Y
T
T
R
N
I
L
I
A
V
G
G
R
Baker's Yeast
Sacchar. cerevisiae
P41921
483
53422
N146
A
R
F
N
K
D
G
N
V
E
V
Q
K
R
D
Red Bread Mold
Neurospora crassa
Q873E8
468
50294
L131
P
N
S
V
E
V
T
L
D
D
G
T
K
S
V
Conservation
Percent
Protein Identity:
100
76.5
46.5
44.3
N.A.
74.4
70.1
N.A.
72.1
66.5
64.5
64
N.A.
45.9
N.A.
47.8
N.A.
Protein Similarity:
100
76.7
57.9
56.3
N.A.
80.7
73.9
N.A.
82.1
78.4
77.8
77.1
N.A.
59
N.A.
62.9
N.A.
P-Site Identity:
100
13.3
6.6
13.3
N.A.
13.3
0
N.A.
80
0
6.6
26.6
N.A.
13.3
N.A.
66.6
N.A.
P-Site Similarity:
100
13.3
20
33.3
N.A.
33.3
6.6
N.A.
86.6
20
26.6
33.3
N.A.
20
N.A.
80
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
33.4
27.7
26.5
Protein Similarity:
N.A.
N.A.
N.A.
49.9
44.2
41.6
P-Site Identity:
N.A.
N.A.
N.A.
13.3
13.3
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
20
26.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
20
0
7
7
0
7
7
0
7
34
27
7
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
7
0
7
0
0
7
7
0
0
0
0
7
% D
% Glu:
7
7
20
0
34
0
7
0
20
14
20
0
0
14
0
% E
% Phe:
0
0
14
7
0
0
14
7
0
0
0
0
27
0
27
% F
% Gly:
0
0
27
0
0
7
7
7
7
0
14
14
34
7
7
% G
% His:
0
0
0
0
7
7
0
7
0
0
0
0
0
0
0
% H
% Ile:
0
7
0
0
7
14
20
14
14
14
0
0
0
0
7
% I
% Lys:
20
27
0
40
20
7
0
0
0
0
0
7
14
0
0
% K
% Leu:
34
7
7
7
7
0
0
7
7
0
0
0
0
14
20
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
7
7
0
14
0
0
7
7
0
20
0
0
0
0
0
% N
% Pro:
7
0
0
0
0
0
0
0
0
0
7
7
0
7
7
% P
% Gln:
0
0
0
7
0
0
0
0
0
0
0
14
7
7
0
% Q
% Arg:
7
40
7
0
0
7
0
7
0
7
7
14
14
14
14
% R
% Ser:
0
7
14
0
7
7
0
0
7
0
7
0
0
7
0
% S
% Thr:
0
0
0
7
14
14
27
7
27
7
14
14
0
7
0
% T
% Val:
0
0
0
7
7
27
7
7
7
0
7
7
0
20
14
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
7
0
0
0
7
34
0
0
0
20
7
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _