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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TXNRD1 All Species: 18.79
Human Site: Y572 Identified Species: 29.52
UniProt: Q16881 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q16881 NP_001087240.1 649 70906 Y572 S R D N N K C Y A K I I C N T
Chimpanzee Pan troglodytes NP_001116141 499 54568 N428 C Y A K I I C N T K D N E R V
Rhesus Macaque Macaca mulatta NP_001152971 524 56314 C452 Q C Y V K M V C L R E P P Q L
Dog Lupus familis XP_850181 509 55065 V438 S Q C Y V K M V C L R K P P Q
Cat Felis silvestris
Mouse Mus musculus Q9JMH6 613 66915 Y536 S R D N N K C Y A K I I C N L
Rat Rattus norvegicus O89049 498 54218 C427 K C Y A K V I C N L K D N E R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507796 621 68478 Y546 S R D N N K C Y A K I I C N I
Chicken Gallus gallus NP_001116249 606 66439 Y529 G R D N N T C Y A K I I C N K
Frog Xenopus laevis NP_001087660 596 65709 F521 S R D N N T C F A K I I C N K
Zebra Danio Brachydanio rerio NP_898895 602 65949 Y525 G R D N N K C Y A K I I C N K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P91938 596 64304 Y519 Q K S V R Y C Y L K A V A E R
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q17745 667 74094 C588 E R M D K D H C Y L K M I C L
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P42770 565 60834 G494 A N T N K V L G V H M C G E D
Baker's Yeast Sacchar. cerevisiae P41921 483 53422 Y412 N S K F T A M Y Y A M L S E K
Red Bread Mold Neurospora crassa Q873E8 468 50294 A397 S F T A M Y Y A M M K P E D K
Conservation
Percent
Protein Identity: 100 76.5 46.5 44.3 N.A. 74.4 70.1 N.A. 72.1 66.5 64.5 64 N.A. 45.9 N.A. 47.8 N.A.
Protein Similarity: 100 76.7 57.9 56.3 N.A. 80.7 73.9 N.A. 82.1 78.4 77.8 77.1 N.A. 59 N.A. 62.9 N.A.
P-Site Identity: 100 13.3 0 13.3 N.A. 93.3 0 N.A. 93.3 80 80 86.6 N.A. 20 N.A. 6.6 N.A.
P-Site Similarity: 100 13.3 6.6 20 N.A. 93.3 0 N.A. 93.3 80 86.6 86.6 N.A. 33.3 N.A. 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 33.4 27.7 26.5
Protein Similarity: N.A. N.A. N.A. 49.9 44.2 41.6
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 6.6
P-Site Similarity: N.A. N.A. N.A. 20 26.6 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 7 14 0 7 0 7 40 7 7 0 7 0 0 % A
% Cys: 7 14 7 0 0 0 54 20 7 0 0 7 40 7 0 % C
% Asp: 0 0 40 7 0 7 0 0 0 0 7 7 0 7 7 % D
% Glu: 7 0 0 0 0 0 0 0 0 0 7 0 14 27 0 % E
% Phe: 0 7 0 7 0 0 0 7 0 0 0 0 0 0 0 % F
% Gly: 14 0 0 0 0 0 0 7 0 0 0 0 7 0 0 % G
% His: 0 0 0 0 0 0 7 0 0 7 0 0 0 0 0 % H
% Ile: 0 0 0 0 7 7 7 0 0 0 40 40 7 0 7 % I
% Lys: 7 7 7 7 27 34 0 0 0 54 20 7 0 0 34 % K
% Leu: 0 0 0 0 0 0 7 0 14 20 0 7 0 0 20 % L
% Met: 0 0 7 0 7 7 14 0 7 7 14 7 0 0 0 % M
% Asn: 7 7 0 47 40 0 0 7 7 0 0 7 7 40 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 14 14 7 0 % P
% Gln: 14 7 0 0 0 0 0 0 0 0 0 0 0 7 7 % Q
% Arg: 0 47 0 0 7 0 0 0 0 7 7 0 0 7 14 % R
% Ser: 40 7 7 0 0 0 0 0 0 0 0 0 7 0 0 % S
% Thr: 0 0 14 0 7 14 0 0 7 0 0 0 0 0 7 % T
% Val: 0 0 0 14 7 14 7 7 7 0 0 7 0 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 7 14 7 0 14 7 47 14 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _