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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GEN1 All Species: 16.67
Human Site: T786 Identified Species: 30.56
UniProt: Q17RS7 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q17RS7 NP_001123481.1 908 102884 T786 R K V D M Q T T R K I L M K K
Chimpanzee Pan troglodytes XP_001136471 908 102886 T786 R K V D M Q T T R K I L M K K
Rhesus Macaque Macaca mulatta XP_001092312 907 102641 T785 R K V D M Q T T Q K I L M K K
Dog Lupus familis XP_540093 908 102344 T786 S K K V D L Q T T Q K S V M K
Cat Felis silvestris
Mouse Mus musculus Q8BMI4 908 101761 T779 P R V A V K T T K N L V M K N
Rat Rattus norvegicus NP_001100187 908 102307 S786 T K N L V K K S S V C L K R D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518788 839 92658 G691 E K T D V Q N G Q N Q K T K R
Chicken Gallus gallus XP_419963 941 105105 S811 V C Q G K C S S S E D S D D G
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VRJ0 726 82516 L605 A E D L S L R L A Q M S L G N
Honey Bee Apis mellifera XP_001120033 614 70598 K493 A E K R R Q K K T E K V L T N
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_793916 1102 120745 Q955 R I H S E S V Q D G P K C T P
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001169528 638 71262 D517 V P Q V L M D D G C C F L L T
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LPD2 599 67201 L478 E E E S V D P L D G L N E P Q
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.2 94.8 79.1 N.A. 70 70 N.A. 35.9 44.4 N.A. N.A. N.A. 28.2 27.4 N.A. 25.8
Protein Similarity: 100 99.6 96.9 87.5 N.A. 80.7 80.9 N.A. 50.4 60 N.A. N.A. N.A. 44.4 42.6 N.A. 41.7
P-Site Identity: 100 100 93.3 20 N.A. 33.3 13.3 N.A. 26.6 0 N.A. N.A. N.A. 0 6.6 N.A. 6.6
P-Site Similarity: 100 100 100 33.3 N.A. 73.3 40 N.A. 46.6 20 N.A. N.A. N.A. 26.6 33.3 N.A. 6.6
Percent
Protein Identity: N.A. 25 N.A. 25.1 N.A. N.A.
Protein Similarity: N.A. 40.9 N.A. 38.1 N.A. N.A.
P-Site Identity: N.A. 0 N.A. 0 N.A. N.A.
P-Site Similarity: N.A. 13.3 N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 16 0 0 8 0 0 0 0 8 0 0 0 0 0 0 % A
% Cys: 0 8 0 0 0 8 0 0 0 8 16 0 8 0 0 % C
% Asp: 0 0 8 31 8 8 8 8 16 0 8 0 8 8 8 % D
% Glu: 16 24 8 0 8 0 0 0 0 16 0 0 8 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % F
% Gly: 0 0 0 8 0 0 0 8 8 16 0 0 0 8 8 % G
% His: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 8 0 0 0 0 0 0 0 0 24 0 0 0 0 % I
% Lys: 0 47 16 0 8 16 16 8 8 24 16 16 8 39 31 % K
% Leu: 0 0 0 16 8 16 0 16 0 0 16 31 24 8 0 % L
% Met: 0 0 0 0 24 8 0 0 0 0 8 0 31 8 0 % M
% Asn: 0 0 8 0 0 0 8 0 0 16 0 8 0 0 24 % N
% Pro: 8 8 0 0 0 0 8 0 0 0 8 0 0 8 8 % P
% Gln: 0 0 16 0 0 39 8 8 16 16 8 0 0 0 8 % Q
% Arg: 31 8 0 8 8 0 8 0 16 0 0 0 0 8 8 % R
% Ser: 8 0 0 16 8 8 8 16 16 0 0 24 0 0 0 % S
% Thr: 8 0 8 0 0 0 31 39 16 0 0 0 8 16 8 % T
% Val: 16 0 31 16 31 0 8 0 0 8 0 16 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _