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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AAK1
All Species:
10.3
Human Site:
S523
Identified Species:
32.38
UniProt:
Q2M2I8
Number Species:
7
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q2M2I8
NP_055726.3
863
93578
S523
P
V
V
S
Q
G
G
S
Q
Q
Q
L
M
Q
N
Chimpanzee
Pan troglodytes
XP_001138187
865
93810
S524
P
V
V
S
Q
G
G
S
Q
Q
Q
L
M
Q
N
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_531855
473
51892
I173
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
Cat
Felis silvestris
Mouse
Mus musculus
Q3UHJ0
959
103328
A532
P
V
G
S
Q
G
G
A
Q
Q
Q
L
M
Q
N
Rat
Rattus norvegicus
P0C1X8
962
103742
S536
P
V
V
S
Q
G
G
S
Q
Q
Q
L
M
Q
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_417663
953
102927
P518
P
V
M
Q
Q
G
A
P
A
Q
Q
Q
L
M
Q
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_625109
598
65629
K298
I
A
F
Q
I
L
G
K
E
C
P
V
Q
N
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P40494
810
91014
S494
I
T
S
K
S
L
S
S
T
K
E
I
A
A
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
N.A.
53.7
N.A.
80.7
79.9
N.A.
N.A.
71.4
N.A.
N.A.
N.A.
N.A.
36.7
N.A.
N.A.
Protein Similarity:
100
99.6
N.A.
54.4
N.A.
83.1
82.7
N.A.
N.A.
77.9
N.A.
N.A.
N.A.
N.A.
50
N.A.
N.A.
P-Site Identity:
100
100
N.A.
6.6
N.A.
86.6
100
N.A.
N.A.
40
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
100
100
N.A.
13.3
N.A.
93.3
100
N.A.
N.A.
53.3
N.A.
N.A.
N.A.
N.A.
20
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
22
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
38.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
13
0
0
0
0
13
13
13
0
0
0
13
13
0
% A
% Cys:
0
0
13
0
0
0
0
0
0
13
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
13
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
13
0
13
0
0
0
13
% E
% Phe:
0
0
13
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
13
0
0
63
63
0
0
0
0
0
0
0
0
% G
% His:
13
0
0
0
0
0
0
0
13
0
0
0
0
0
0
% H
% Ile:
25
0
0
0
13
0
13
13
0
0
0
13
0
0
0
% I
% Lys:
0
0
0
25
0
0
0
13
0
13
0
0
13
0
0
% K
% Leu:
0
0
0
0
0
25
0
0
0
0
0
63
13
0
13
% L
% Met:
0
0
13
0
0
0
0
0
0
0
0
0
50
13
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
13
50
% N
% Pro:
63
0
0
0
0
13
0
13
0
0
13
0
0
0
13
% P
% Gln:
0
13
0
25
63
0
0
0
50
63
63
13
13
50
13
% Q
% Arg:
0
0
0
0
0
0
0
0
0
13
0
0
0
0
0
% R
% Ser:
0
0
13
50
13
0
13
50
0
0
0
0
0
0
0
% S
% Thr:
0
13
0
0
13
0
0
0
13
0
0
0
0
0
0
% T
% Val:
0
63
38
0
0
0
0
0
0
0
0
13
0
13
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _