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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HYAL4
All Species:
9.39
Human Site:
S456
Identified Species:
22.96
UniProt:
Q2M3T9
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q2M3T9
NP_036401.2
481
54249
S456
I
K
T
A
D
G
C
S
G
V
S
P
S
P
G
Chimpanzee
Pan troglodytes
XP_527872
476
53770
A452
D
C
R
E
I
K
T
A
D
G
C
S
G
V
S
Rhesus Macaque
Macaca mulatta
XP_001086758
481
54558
S456
V
K
T
A
D
G
C
S
G
V
S
P
F
P
G
Dog
Lupus familis
XP_532444
481
54599
S456
T
K
T
A
D
G
C
S
G
V
F
S
F
S
S
Cat
Felis silvestris
Mouse
Mus musculus
Q05A56
481
54366
S456
M
T
E
A
S
G
P
S
G
L
S
L
S
S
S
Rat
Rattus norvegicus
Q62803
512
58394
N456
M
R
S
I
Q
D
V
N
V
C
M
G
D
N
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507903
484
55440
P456
V
N
P
S
E
E
P
P
G
S
P
A
T
L
L
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001080777
487
56182
A456
Q
R
R
T
N
G
G
A
V
A
T
G
P
C
G
Zebra Danio
Brachydanio rerio
XP_001922123
503
57814
E456
I
E
P
E
E
T
E
E
D
N
M
I
K
E
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Q08169
382
44241
P358
Y
L
N
N
E
L
G
P
A
V
K
R
I
A
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.7
95.6
88.3
N.A.
79.6
37.8
N.A.
68.5
N.A.
44.5
53.4
N.A.
N.A.
27.8
N.A.
N.A.
Protein Similarity:
100
98.7
98.5
94.3
N.A.
89.1
54.4
N.A.
81.1
N.A.
60.3
69.7
N.A.
N.A.
43.6
N.A.
N.A.
P-Site Identity:
100
0
86.6
60
N.A.
40
0
N.A.
6.6
N.A.
13.3
6.6
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
100
6.6
93.3
60
N.A.
53.3
26.6
N.A.
33.3
N.A.
40
20
N.A.
N.A.
13.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
40
0
0
0
20
10
10
0
10
0
10
0
% A
% Cys:
0
10
0
0
0
0
30
0
0
10
10
0
0
10
0
% C
% Asp:
10
0
0
0
30
10
0
0
20
0
0
0
10
0
0
% D
% Glu:
0
10
10
20
30
10
10
10
0
0
0
0
0
10
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
10
0
20
0
0
% F
% Gly:
0
0
0
0
0
50
20
0
50
10
0
20
10
0
30
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
20
0
0
10
10
0
0
0
0
0
0
10
10
0
0
% I
% Lys:
0
30
0
0
0
10
0
0
0
0
10
0
10
0
0
% K
% Leu:
0
10
0
0
0
10
0
0
0
10
0
10
0
10
20
% L
% Met:
20
0
0
0
0
0
0
0
0
0
20
0
0
0
0
% M
% Asn:
0
10
10
10
10
0
0
10
0
10
0
0
0
10
10
% N
% Pro:
0
0
20
0
0
0
20
20
0
0
10
20
10
20
0
% P
% Gln:
10
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
20
20
0
0
0
0
0
0
0
0
10
0
0
0
% R
% Ser:
0
0
10
10
10
0
0
40
0
10
30
20
20
20
30
% S
% Thr:
10
10
30
10
0
10
10
0
0
0
10
0
10
0
0
% T
% Val:
20
0
0
0
0
0
10
0
20
40
0
0
0
10
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _