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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PROX2
All Species:
8.79
Human Site:
S222
Identified Species:
17.58
UniProt:
Q3B8N5
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q3B8N5
NP_001073877
592
65586
S222
L
P
S
G
A
P
A
S
L
E
I
L
R
K
E
Chimpanzee
Pan troglodytes
XP_522907
592
65532
S222
L
P
S
G
A
P
A
S
L
E
I
L
R
K
E
Rhesus Macaque
Macaca mulatta
XP_001088672
592
65588
S222
L
P
S
G
A
P
D
S
L
E
I
L
R
K
E
Dog
Lupus familis
XP_858135
737
83203
L348
L
Q
P
E
G
K
H
L
A
E
T
L
K
Q
E
Cat
Felis silvestris
Mouse
Mus musculus
Q8BII1
593
65740
L226
C
P
S
G
P
R
A
L
V
E
T
L
R
K
E
Rat
Rattus norvegicus
XP_234418
593
65234
L225
C
P
S
G
P
R
A
L
V
E
T
L
R
K
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517520
680
74782
F283
L
P
S
E
G
R
G
F
S
E
T
L
K
E
E
Chicken
Gallus gallus
Q91018
736
83123
L347
F
H
P
E
G
K
H
L
A
E
T
L
K
Q
E
Frog
Xenopus laevis
NP_001084172
740
83918
D334
K
K
D
A
P
P
K
D
K
D
N
L
H
H
P
Zebra Danio
Brachydanio rerio
NP_001121764
582
65976
F224
S
D
R
A
V
K
S
F
Q
E
T
L
K
C
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34522
586
65798
G195
Q
I
N
V
T
V
G
G
T
E
E
A
E
E
T
Sea Urchin
Strong. purpuratus
XP_781578
723
81042
V313
D
R
T
T
S
Y
I
V
R
Q
T
L
K
E
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.4
93.2
33.1
N.A.
64.7
67.4
N.A.
39.7
33.4
32.2
35.1
N.A.
N.A.
N.A.
22.9
27.2
Protein Similarity:
100
97.8
95
45.4
N.A.
75.2
76.3
N.A.
49.7
45.2
46.3
48.6
N.A.
N.A.
N.A.
39.7
41.7
P-Site Identity:
100
100
93.3
26.6
N.A.
60
60
N.A.
40
20
13.3
20
N.A.
N.A.
N.A.
6.6
13.3
P-Site Similarity:
100
100
93.3
40
N.A.
66.6
66.6
N.A.
53.3
33.3
20
33.3
N.A.
N.A.
N.A.
20
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
17
25
0
34
0
17
0
0
9
0
0
0
% A
% Cys:
17
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% C
% Asp:
9
9
9
0
0
0
9
9
0
9
0
0
0
0
0
% D
% Glu:
0
0
0
25
0
0
0
0
0
84
9
0
9
25
84
% E
% Phe:
9
0
0
0
0
0
0
17
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
42
25
0
17
9
0
0
0
0
0
0
0
% G
% His:
0
9
0
0
0
0
17
0
0
0
0
0
9
9
0
% H
% Ile:
0
9
0
0
0
0
9
0
0
0
25
0
0
0
0
% I
% Lys:
9
9
0
0
0
25
9
0
9
0
0
0
42
42
0
% K
% Leu:
42
0
0
0
0
0
0
34
25
0
0
92
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
9
0
0
0
0
0
0
0
9
0
0
0
0
% N
% Pro:
0
50
17
0
25
34
0
0
0
0
0
0
0
0
9
% P
% Gln:
9
9
0
0
0
0
0
0
9
9
0
0
0
17
0
% Q
% Arg:
0
9
9
0
0
25
0
0
9
0
0
0
42
0
0
% R
% Ser:
9
0
50
0
9
0
9
25
9
0
0
0
0
0
0
% S
% Thr:
0
0
9
9
9
0
0
0
9
0
59
0
0
0
9
% T
% Val:
0
0
0
9
9
9
0
9
17
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _