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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PROX2
All Species:
10.61
Human Site:
S403
Identified Species:
21.21
UniProt:
Q3B8N5
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q3B8N5
NP_001073877
592
65586
S403
Q
C
P
L
P
F
T
S
A
H
L
E
S
L
P
Chimpanzee
Pan troglodytes
XP_522907
592
65532
S403
Q
C
P
L
P
F
T
S
A
H
L
E
S
L
P
Rhesus Macaque
Macaca mulatta
XP_001088672
592
65588
S403
Q
C
P
L
P
F
T
S
A
H
L
E
S
L
P
Dog
Lupus familis
XP_858135
737
83203
P540
L
S
H
H
P
C
S
P
A
H
P
P
S
T
A
Cat
Felis silvestris
Mouse
Mus musculus
Q8BII1
593
65740
P399
Q
L
P
L
S
L
T
P
V
H
L
E
S
R
P
Rat
Rattus norvegicus
XP_234418
593
65234
P398
R
L
P
L
S
F
T
P
V
H
L
E
S
R
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517520
680
74782
P449
Q
Y
P
A
P
F
A
P
T
Q
M
G
R
P
P
Chicken
Gallus gallus
Q91018
736
83123
A545
S
P
A
H
P
P
S
A
A
E
G
L
S
L
S
Frog
Xenopus laevis
NP_001084172
740
83918
S547
S
P
A
H
P
P
S
S
T
E
G
L
S
L
S
Zebra Danio
Brachydanio rerio
NP_001121764
582
65976
R389
Q
L
Q
L
Q
H
Q
R
A
A
P
A
G
L
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34522
586
65798
A381
A
S
P
L
S
A
S
A
S
P
P
L
S
R
F
Sea Urchin
Strong. purpuratus
XP_781578
723
81042
L517
H
R
S
S
P
G
D
L
S
H
I
S
S
G
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.4
93.2
33.1
N.A.
64.7
67.4
N.A.
39.7
33.4
32.2
35.1
N.A.
N.A.
N.A.
22.9
27.2
Protein Similarity:
100
97.8
95
45.4
N.A.
75.2
76.3
N.A.
49.7
45.2
46.3
48.6
N.A.
N.A.
N.A.
39.7
41.7
P-Site Identity:
100
100
100
26.6
N.A.
60
60
N.A.
33.3
26.6
26.6
26.6
N.A.
N.A.
N.A.
20
20
P-Site Similarity:
100
100
100
33.3
N.A.
60
66.6
N.A.
40
40
33.3
26.6
N.A.
N.A.
N.A.
40
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
17
9
0
9
9
17
50
9
0
9
0
0
9
% A
% Cys:
0
25
0
0
0
9
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
17
0
42
0
0
9
% E
% Phe:
0
0
0
0
0
42
0
0
0
0
0
0
0
0
9
% F
% Gly:
0
0
0
0
0
9
0
0
0
0
17
9
9
9
0
% G
% His:
9
0
9
25
0
9
0
0
0
59
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
9
25
0
59
0
9
0
9
0
0
42
25
0
50
9
% L
% Met:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
17
59
0
67
17
0
34
0
9
25
9
0
9
50
% P
% Gln:
50
0
9
0
9
0
9
0
0
9
0
0
0
0
0
% Q
% Arg:
9
9
0
0
0
0
0
9
0
0
0
0
9
25
0
% R
% Ser:
17
17
9
9
25
0
34
34
17
0
0
9
84
0
17
% S
% Thr:
0
0
0
0
0
0
42
0
17
0
0
0
0
9
0
% T
% Val:
0
0
0
0
0
0
0
0
17
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _