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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PLEKHG6 All Species: 7.88
Human Site: S543 Identified Species: 17.33
UniProt: Q3KR16 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q3KR16 NP_001138328.1 790 88961 S543 E S P S T R P S T P S L E G S
Chimpanzee Pan troglodytes XP_001160991 790 89043 S543 E S P S T R P S T P S L E G S
Rhesus Macaque Macaca mulatta XP_001118229 751 83748 A519 D C T G R K R A I L F T L L T
Dog Lupus familis XP_534913 800 89979 G543 D Q D Q E S S G T R P S S P S
Cat Felis silvestris
Mouse Mus musculus Q8R0J1 787 89106 S543 E S P S T R P S T P S P S P E
Rat Rattus norvegicus Q6RFZ7 1039 115766 E754 E E D E Q E E E G E E S G T S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518326 472 55138 A240 D E P R T K D A I I T M I G S
Chicken Gallus gallus XP_423692 451 48811 P219 L K G P F G S P S D S T S V S
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001923813 860 97118 I521 S T S S S P S I H H R E T L S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_392491 767 84898 V525 E P T S L G L V Y L N E Y G A
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_782471 866 97476 Q596 E M Q P D D P Q T P I A A L M
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 83.6 80.5 N.A. 81.1 32.4 N.A. 31.1 20.6 N.A. 33.1 N.A. N.A. 26.4 N.A. 21.4
Protein Similarity: 100 99.8 86.3 87.5 N.A. 88.2 45.2 N.A. 43.1 34 N.A. 50.5 N.A. N.A. 44.4 N.A. 40.3
P-Site Identity: 100 100 0 13.3 N.A. 73.3 13.3 N.A. 26.6 13.3 N.A. 13.3 N.A. N.A. 20 N.A. 26.6
P-Site Similarity: 100 100 26.6 20 N.A. 73.3 13.3 N.A. 60 20 N.A. 26.6 N.A. N.A. 33.3 N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 19 0 0 0 10 10 0 10 % A
% Cys: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 28 0 19 0 10 10 10 0 0 10 0 0 0 0 0 % D
% Glu: 55 19 0 10 10 10 10 10 0 10 10 19 19 0 10 % E
% Phe: 0 0 0 0 10 0 0 0 0 0 10 0 0 0 0 % F
% Gly: 0 0 10 10 0 19 0 10 10 0 0 0 10 37 0 % G
% His: 0 0 0 0 0 0 0 0 10 10 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 10 19 10 10 0 10 0 0 % I
% Lys: 0 10 0 0 0 19 0 0 0 0 0 0 0 0 0 % K
% Leu: 10 0 0 0 10 0 10 0 0 19 0 19 10 28 0 % L
% Met: 0 10 0 0 0 0 0 0 0 0 0 10 0 0 10 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % N
% Pro: 0 10 37 19 0 10 37 10 0 37 10 10 0 19 0 % P
% Gln: 0 10 10 10 10 0 0 10 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 10 10 28 10 0 0 10 10 0 0 0 0 % R
% Ser: 10 28 10 46 10 10 28 28 10 0 37 19 28 0 64 % S
% Thr: 0 10 19 0 37 0 0 0 46 0 10 19 10 10 10 % T
% Val: 0 0 0 0 0 0 0 10 0 0 0 0 0 10 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 10 0 0 0 10 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _