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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PLEKHG6 All Species: 10
Human Site: T623 Identified Species: 22
UniProt: Q3KR16 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q3KR16 NP_001138328.1 790 88961 T623 D P R L T F S T L E L R D I P
Chimpanzee Pan troglodytes XP_001160991 790 89043 T623 D P R L T F S T L E L R D I P
Rhesus Macaque Macaca mulatta XP_001118229 751 83748 S599 T G S R S P L S R L R Q R A L
Dog Lupus familis XP_534913 800 89979 R623 R L R P Q A L R R D P R L T F
Cat Felis silvestris
Mouse Mus musculus Q8R0J1 787 89106 S623 R D P R L T F S T L E L R D V
Rat Rattus norvegicus Q6RFZ7 1039 115766 L834 I T P T S E L L P L G P V D G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518326 472 55138 S320 R Q L L L E G S M R M K E G K
Chicken Gallus gallus XP_423692 451 48811 L299 A E E G P E A L A P R P P S P
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001923813 860 97118 S601 D L D P E S R S L S I D S A Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_392491 767 84898 S605 I P K T P R G S S R A S R V S
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_782471 866 97476 Q676 V M N G T G V Q E N N S N N Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 83.6 80.5 N.A. 81.1 32.4 N.A. 31.1 20.6 N.A. 33.1 N.A. N.A. 26.4 N.A. 21.4
Protein Similarity: 100 99.8 86.3 87.5 N.A. 88.2 45.2 N.A. 43.1 34 N.A. 50.5 N.A. N.A. 44.4 N.A. 40.3
P-Site Identity: 100 100 0 13.3 N.A. 0 0 N.A. 6.6 6.6 N.A. 13.3 N.A. N.A. 6.6 N.A. 6.6
P-Site Similarity: 100 100 20 20 N.A. 6.6 6.6 N.A. 40 13.3 N.A. 26.6 N.A. N.A. 26.6 N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 0 0 0 10 10 0 10 0 10 0 0 19 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 28 10 10 0 0 0 0 0 0 10 0 10 19 19 0 % D
% Glu: 0 10 10 0 10 28 0 0 10 19 10 0 10 0 0 % E
% Phe: 0 0 0 0 0 19 10 0 0 0 0 0 0 0 10 % F
% Gly: 0 10 0 19 0 10 19 0 0 0 10 0 0 10 10 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 19 0 0 0 0 0 0 0 0 0 10 0 0 19 0 % I
% Lys: 0 0 10 0 0 0 0 0 0 0 0 10 0 0 10 % K
% Leu: 0 19 10 28 19 0 28 19 28 28 19 10 10 0 10 % L
% Met: 0 10 0 0 0 0 0 0 10 0 10 0 0 0 0 % M
% Asn: 0 0 10 0 0 0 0 0 0 10 10 0 10 10 0 % N
% Pro: 0 28 19 19 19 10 0 0 10 10 10 19 10 0 28 % P
% Gln: 0 10 0 0 10 0 0 10 0 0 0 10 0 0 10 % Q
% Arg: 28 0 28 19 0 10 10 10 19 19 19 28 28 0 0 % R
% Ser: 0 0 10 0 19 10 19 46 10 10 0 19 10 10 10 % S
% Thr: 10 10 0 19 28 10 0 19 10 0 0 0 0 10 0 % T
% Val: 10 0 0 0 0 0 10 0 0 0 0 0 10 10 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _