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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TBC1D25 All Species: 18.48
Human Site: S270 Identified Species: 40.67
UniProt: Q3MII6 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.2
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q3MII6 NP_002527.1 688 76357 S270 R E Y E Q L K S E W A Q R A N
Chimpanzee Pan troglodytes XP_001139235 548 60665 E221 R A S P E D L E F I R S T V L
Rhesus Macaque Macaca mulatta XP_001098742 688 76366 S270 R E Y E Q L K S E W A Q R A S
Dog Lupus familis XP_548985 687 76023 S269 R E Y E Q L K S E W A Q R A S
Cat Felis silvestris
Mouse Mus musculus A1A5B6 742 82556 S324 R E Y E Q L K S E W A Q R V N
Rat Rattus norvegicus NP_001100425 688 76364 S270 R E Y E Q L K S E W A Q R V N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520975 664 74736 D254 L K D V L R T D R A H P Y Y A
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001121708 863 95814 L262 E F I R G N V L K D V L R T D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_611029 1098 122546 Y268 M R R K S E Q Y C R L R D T W
Honey Bee Apis mellifera XP_395220 875 99616 L253 L R E R W K T L V Q K G Q N V
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001192002 715 80854 L267 E N P N G I K L F N V L T T Y
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 78.1 99.2 94.7 N.A. 87.1 93.5 N.A. 66.7 N.A. N.A. 56.6 N.A. 27.1 37 N.A. 43.3
Protein Similarity: 100 78.7 99.7 97 N.A. 88.8 95.3 N.A. 75.4 N.A. N.A. 64.7 N.A. 38.3 50.9 N.A. 59.4
P-Site Identity: 100 6.6 93.3 93.3 N.A. 93.3 93.3 N.A. 0 N.A. N.A. 6.6 N.A. 0 0 N.A. 6.6
P-Site Similarity: 100 13.3 100 100 N.A. 93.3 93.3 N.A. 6.6 N.A. N.A. 20 N.A. 20 6.6 N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 10 0 0 0 0 0 0 0 10 46 0 0 28 10 % A
% Cys: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % C
% Asp: 0 0 10 0 0 10 0 10 0 10 0 0 10 0 10 % D
% Glu: 19 46 10 46 10 10 0 10 46 0 0 0 0 0 0 % E
% Phe: 0 10 0 0 0 0 0 0 19 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 19 0 0 0 0 0 0 10 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % H
% Ile: 0 0 10 0 0 10 0 0 0 10 0 0 0 0 0 % I
% Lys: 0 10 0 10 0 10 55 0 10 0 10 0 0 0 0 % K
% Leu: 19 0 0 0 10 46 10 28 0 0 10 19 0 0 10 % L
% Met: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 10 0 10 0 10 0 0 0 10 0 0 0 10 28 % N
% Pro: 0 0 10 10 0 0 0 0 0 0 0 10 0 0 0 % P
% Gln: 0 0 0 0 46 0 10 0 0 10 0 46 10 0 0 % Q
% Arg: 55 19 10 19 0 10 0 0 10 10 10 10 55 0 0 % R
% Ser: 0 0 10 0 10 0 0 46 0 0 0 10 0 0 19 % S
% Thr: 0 0 0 0 0 0 19 0 0 0 0 0 19 28 0 % T
% Val: 0 0 0 10 0 0 10 0 10 0 19 0 0 28 10 % V
% Trp: 0 0 0 0 10 0 0 0 0 46 0 0 0 0 10 % W
% Tyr: 0 0 46 0 0 0 0 10 0 0 0 0 10 10 10 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _