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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TBC1D25
All Species:
20
Human Site:
S589
Identified Species:
44
UniProt:
Q3MII6
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q3MII6
NP_002527.1
688
76357
S589
P
L
M
Q
E
V
G
S
P
K
D
P
G
K
S
Chimpanzee
Pan troglodytes
XP_001139235
548
60665
M494
L
E
H
R
D
H
I
M
R
N
G
L
D
Y
N
Rhesus Macaque
Macaca mulatta
XP_001098742
688
76366
S589
P
L
M
R
E
V
G
S
P
K
D
P
G
K
S
Dog
Lupus familis
XP_548985
687
76023
S588
P
L
M
P
E
L
G
S
P
Q
E
P
G
K
S
Cat
Felis silvestris
Mouse
Mus musculus
A1A5B6
742
82556
S643
P
L
M
Q
E
V
G
S
P
R
D
P
G
K
P
Rat
Rattus norvegicus
NP_001100425
688
76364
S589
P
S
M
P
E
V
G
S
P
R
D
P
G
K
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520975
664
74736
P579
L
G
S
V
S
L
P
P
P
Q
E
F
G
K
G
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001121708
863
95814
N716
G
V
S
S
P
N
T
N
K
P
E
G
G
G
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_611029
1098
122546
P1004
T
A
A
A
L
P
P
P
T
E
F
G
G
G
N
Honey Bee
Apis mellifera
XP_395220
875
99616
S615
V
L
R
D
E
P
S
S
P
D
D
P
T
D
F
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001192002
715
80854
S577
L
L
N
S
L
P
K
S
P
P
K
S
P
Q
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
78.1
99.2
94.7
N.A.
87.1
93.5
N.A.
66.7
N.A.
N.A.
56.6
N.A.
27.1
37
N.A.
43.3
Protein Similarity:
100
78.7
99.7
97
N.A.
88.8
95.3
N.A.
75.4
N.A.
N.A.
64.7
N.A.
38.3
50.9
N.A.
59.4
P-Site Identity:
100
0
93.3
73.3
N.A.
86.6
80
N.A.
20
N.A.
N.A.
6.6
N.A.
6.6
40
N.A.
20
P-Site Similarity:
100
20
100
93.3
N.A.
93.3
86.6
N.A.
40
N.A.
N.A.
26.6
N.A.
20
40
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
10
10
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
10
10
0
0
0
0
10
46
0
10
10
0
% D
% Glu:
0
10
0
0
55
0
0
0
0
10
28
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
10
10
0
0
10
% F
% Gly:
10
10
0
0
0
0
46
0
0
0
10
19
73
19
10
% G
% His:
0
0
10
0
0
10
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
10
% I
% Lys:
0
0
0
0
0
0
10
0
10
19
10
0
0
55
0
% K
% Leu:
28
55
0
0
19
19
0
0
0
0
0
10
0
0
0
% L
% Met:
0
0
46
0
0
0
0
10
0
0
0
0
0
0
0
% M
% Asn:
0
0
10
0
0
10
0
10
0
10
0
0
0
0
19
% N
% Pro:
46
0
0
19
10
28
19
19
73
19
0
55
10
0
10
% P
% Gln:
0
0
0
19
0
0
0
0
0
19
0
0
0
10
0
% Q
% Arg:
0
0
10
19
0
0
0
0
10
19
0
0
0
0
10
% R
% Ser:
0
10
19
19
10
0
10
64
0
0
0
10
0
0
37
% S
% Thr:
10
0
0
0
0
0
10
0
10
0
0
0
10
0
0
% T
% Val:
10
10
0
10
0
37
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _