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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TBC1D25 All Species: 22.73
Human Site: Y245 Identified Species: 50
UniProt: Q3MII6 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q3MII6 NP_002527.1 688 76357 Y245 W R Y L L N V Y P D G L T G R
Chimpanzee Pan troglodytes XP_001139235 548 60665 Y196 T G R E R M D Y M K R K S R E
Rhesus Macaque Macaca mulatta XP_001098742 688 76366 Y245 W R Y L L N V Y P D G L T G R
Dog Lupus familis XP_548985 687 76023 Y244 W R Y L L N V Y P D G L T G R
Cat Felis silvestris
Mouse Mus musculus A1A5B6 742 82556 Y299 W R Y L L N V Y P D G L T G R
Rat Rattus norvegicus NP_001100425 688 76364 Y245 W R Y L L N V Y P D G L T G R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520975 664 74736 E229 E Y D Q L K S E W N Q R A S Q
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001121708 863 95814 E237 Y M K R K T R E Y D Q L K S E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_611029 1098 122546 Y243 W K H L L N V Y P G G A N G L
Honey Bee Apis mellifera XP_395220 875 99616 S228 N V Y P E G M S G R E R M D Y
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001192002 715 80854 R242 K N I K N M V R K D V L R T D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 78.1 99.2 94.7 N.A. 87.1 93.5 N.A. 66.7 N.A. N.A. 56.6 N.A. 27.1 37 N.A. 43.3
Protein Similarity: 100 78.7 99.7 97 N.A. 88.8 95.3 N.A. 75.4 N.A. N.A. 64.7 N.A. 38.3 50.9 N.A. 59.4
P-Site Identity: 100 6.6 100 100 N.A. 100 100 N.A. 6.6 N.A. N.A. 13.3 N.A. 60 6.6 N.A. 20
P-Site Similarity: 100 13.3 100 100 N.A. 100 100 N.A. 20 N.A. N.A. 20 N.A. 73.3 13.3 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 10 10 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 10 0 0 0 10 0 0 64 0 0 0 10 10 % D
% Glu: 10 0 0 10 10 0 0 19 0 0 10 0 0 0 19 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 10 0 0 0 10 0 0 10 10 55 0 0 55 0 % G
% His: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 10 10 10 10 10 10 0 0 10 10 0 10 10 0 0 % K
% Leu: 0 0 0 55 64 0 0 0 0 0 0 64 0 0 10 % L
% Met: 0 10 0 0 0 19 10 0 10 0 0 0 10 0 0 % M
% Asn: 10 10 0 0 10 55 0 0 0 10 0 0 10 0 0 % N
% Pro: 0 0 0 10 0 0 0 0 55 0 0 0 0 0 0 % P
% Gln: 0 0 0 10 0 0 0 0 0 0 19 0 0 0 10 % Q
% Arg: 0 46 10 10 10 0 10 10 0 10 10 19 10 10 46 % R
% Ser: 0 0 0 0 0 0 10 10 0 0 0 0 10 19 0 % S
% Thr: 10 0 0 0 0 10 0 0 0 0 0 0 46 10 0 % T
% Val: 0 10 0 0 0 0 64 0 0 0 10 0 0 0 0 % V
% Trp: 55 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % W
% Tyr: 10 10 55 0 0 0 0 64 10 0 0 0 0 0 10 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _