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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSDL1
All Species:
6.67
Human Site:
S266
Identified Species:
11.28
UniProt:
Q3SXM5
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q3SXM5
NP_001139523.1
330
37018
S266
S
N
F
L
H
R
C
S
W
L
V
P
S
P
K
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001112266
330
36970
S266
S
S
F
L
H
R
C
S
W
L
V
P
S
P
K
Dog
Lupus familis
XP_536765
330
37069
P266
G
S
F
L
H
K
C
P
W
L
V
P
S
P
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8BTX9
330
36849
P266
A
S
F
L
H
R
C
P
W
L
A
P
S
P
R
Rat
Rattus norvegicus
Q4V8B7
330
36889
P266
G
S
F
L
R
R
C
P
W
L
A
P
S
P
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509376
330
37373
P266
S
G
F
L
H
S
N
P
W
L
V
P
S
P
K
Chicken
Gallus gallus
Q5ZJG8
331
37589
S266
S
R
V
T
S
K
R
S
F
F
F
P
S
A
E
Frog
Xenopus laevis
Q5XG41
318
34975
P255
R
K
P
T
W
D
K
P
S
P
E
T
Y
V
R
Zebra Danio
Brachydanio rerio
A5WWC6
319
35106
A252
S
L
L
P
F
R
V
A
S
Q
R
P
E
G
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_724023
324
36393
G254
S
D
K
V
R
Q
G
G
L
L
F
P
N
A
Y
Honey Bee
Apis mellifera
XP_393710
291
32768
P229
Q
V
S
N
I
L
V
P
S
A
T
T
Y
A
K
Nematode Worm
Caenorhab. elegans
Q09517
316
34290
A253
S
F
F
T
P
D
G
A
V
F
A
K
S
A
L
Sea Urchin
Strong. purpuratus
XP_788968
356
39637
R266
G
E
T
M
P
R
S
R
F
L
I
P
S
A
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7RYE5
332
36765
P257
R
R
T
S
L
L
I
P
N
P
K
Q
F
V
R
Conservation
Percent
Protein Identity:
100
N.A.
98.4
92.7
N.A.
87.5
86.6
N.A.
86
64.9
43.9
52.1
N.A.
38.7
42.7
35.1
47.7
Protein Similarity:
100
N.A.
99.6
98.1
N.A.
93.9
93.6
N.A.
92.4
80.6
61.5
67.8
N.A.
59.3
57.5
53.9
64.8
P-Site Identity:
100
N.A.
93.3
73.3
N.A.
66.6
60
N.A.
73.3
26.6
0
20
N.A.
20
6.6
20
26.6
P-Site Similarity:
100
N.A.
100
86.6
N.A.
86.6
73.3
N.A.
73.3
46.6
6.6
26.6
N.A.
46.6
6.6
26.6
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
33.1
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
54.8
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
6.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
0
15
0
8
22
0
0
36
8
% A
% Cys:
0
0
0
0
0
0
36
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
0
0
0
15
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
8
0
0
0
0
0
0
0
0
8
0
8
0
8
% E
% Phe:
0
8
50
0
8
0
0
0
15
15
15
0
8
0
0
% F
% Gly:
22
8
0
0
0
0
15
8
0
0
0
0
0
8
0
% G
% His:
0
0
0
0
36
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
8
0
8
0
0
0
8
0
0
0
0
% I
% Lys:
0
8
8
0
0
15
8
0
0
0
8
8
0
0
36
% K
% Leu:
0
8
8
43
8
15
0
0
8
58
0
0
0
0
8
% L
% Met:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
0
8
0
0
8
0
8
0
0
0
8
0
0
% N
% Pro:
0
0
8
8
15
0
0
50
0
15
0
72
0
43
0
% P
% Gln:
8
0
0
0
0
8
0
0
0
8
0
8
0
0
0
% Q
% Arg:
15
15
0
0
15
43
8
8
0
0
8
0
0
0
29
% R
% Ser:
50
29
8
8
8
8
8
22
22
0
0
0
65
0
8
% S
% Thr:
0
0
15
22
0
0
0
0
0
0
8
15
0
0
0
% T
% Val:
0
8
8
8
0
0
15
0
8
0
29
0
0
15
0
% V
% Trp:
0
0
0
0
8
0
0
0
43
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
15
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _