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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSDL1
All Species:
21.52
Human Site:
S58
Identified Species:
36.41
UniProt:
Q3SXM5
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q3SXM5
NP_001139523.1
330
37018
S58
H
F
I
P
R
L
G
S
R
A
D
L
I
K
Q
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001112266
330
36970
S58
H
F
I
P
R
L
G
S
R
A
D
L
I
K
Q
Dog
Lupus familis
XP_536765
330
37069
S58
H
F
I
P
R
L
V
S
R
A
D
L
I
K
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q8BTX9
330
36849
S58
H
F
I
P
R
L
G
S
R
P
D
L
I
K
Q
Rat
Rattus norvegicus
Q4V8B7
330
36889
S58
H
F
I
P
R
L
G
S
R
P
D
L
I
K
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509376
330
37373
S58
H
F
I
P
R
L
V
S
K
A
D
L
I
K
Q
Chicken
Gallus gallus
Q5ZJG8
331
37589
G58
H
A
L
P
K
L
V
G
E
I
D
I
V
K
R
Frog
Xenopus laevis
Q5XG41
318
34975
V58
P
R
I
G
K
W
A
V
V
T
G
A
T
D
G
Zebra Danio
Brachydanio rerio
A5WWC6
319
35106
R58
Y
F
V
P
R
L
V
R
H
R
D
L
S
Q
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_724023
324
36393
W58
L
A
E
K
F
G
N
W
A
V
V
T
G
A
T
Honey Bee
Apis mellifera
XP_393710
291
32768
G36
V
V
T
G
S
T
D
G
I
G
K
A
Y
A
K
Nematode Worm
Caenorhab. elegans
Q09517
316
34290
G60
T
G
A
T
D
G
I
G
K
A
Y
A
F
E
L
Sea Urchin
Strong. purpuratus
XP_788968
356
39637
P59
H
L
Y
P
K
L
R
P
K
R
D
L
V
K
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7RYE5
332
36765
W58
K
Y
G
K
K
G
T
W
A
V
I
T
G
A
S
Conservation
Percent
Protein Identity:
100
N.A.
98.4
92.7
N.A.
87.5
86.6
N.A.
86
64.9
43.9
52.1
N.A.
38.7
42.7
35.1
47.7
Protein Similarity:
100
N.A.
99.6
98.1
N.A.
93.9
93.6
N.A.
92.4
80.6
61.5
67.8
N.A.
59.3
57.5
53.9
64.8
P-Site Identity:
100
N.A.
100
93.3
N.A.
93.3
93.3
N.A.
86.6
33.3
6.6
46.6
N.A.
0
0
6.6
40
P-Site Similarity:
100
N.A.
100
93.3
N.A.
93.3
93.3
N.A.
93.3
66.6
13.3
66.6
N.A.
0
6.6
20
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
33.1
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
54.8
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
15
8
0
0
0
8
0
15
36
0
22
0
22
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
8
0
8
0
0
0
65
0
0
8
0
% D
% Glu:
0
0
8
0
0
0
0
0
8
0
0
0
0
8
8
% E
% Phe:
0
50
0
0
8
0
0
0
0
0
0
0
8
0
0
% F
% Gly:
0
8
8
15
0
22
29
22
0
8
8
0
15
0
8
% G
% His:
58
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% H
% Ile:
0
0
50
0
0
0
8
0
8
8
8
8
43
0
0
% I
% Lys:
8
0
0
15
29
0
0
0
22
0
8
0
0
58
8
% K
% Leu:
8
8
8
0
0
65
0
0
0
0
0
58
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% N
% Pro:
8
0
0
65
0
0
0
8
0
15
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
50
% Q
% Arg:
0
8
0
0
50
0
8
8
36
15
0
0
0
0
8
% R
% Ser:
0
0
0
0
8
0
0
43
0
0
0
0
8
0
8
% S
% Thr:
8
0
8
8
0
8
8
0
0
8
0
15
8
0
8
% T
% Val:
8
8
8
0
0
0
29
8
8
15
8
0
15
0
0
% V
% Trp:
0
0
0
0
0
8
0
15
0
0
0
0
0
0
0
% W
% Tyr:
8
8
8
0
0
0
0
0
0
0
8
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _