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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CRY2 All Species: 13.94
Human Site: S537 Identified Species: 23.59
UniProt: Q49AN0 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q49AN0 NP_001120929.1 593 66947 S537 S H P V A E P S S S Q A G S M
Chimpanzee Pan troglodytes XP_001160595 593 66872 S537 S H P V A E P S S S Q A G S M
Rhesus Macaque Macaca mulatta XP_001113162 593 66839 S537 S H P V A E P S S S Q A G S V
Dog Lupus familis XP_540761 593 66822 S537 S N P V A E P S S S Q T G S M
Cat Felis silvestris
Mouse Mus musculus Q9R194 592 66832 G536 S H P V A E P G S S Q A G S I
Rat Rattus norvegicus Q923I8 594 67204 G536 S H P V A E P G S S Q A G S I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507425 582 65716 G524 S S A A A E S G L G Q A S G S
Chicken Gallus gallus Q8QG60 582 66078 A527 S G P V T D S A P G Q G S S T
Frog Xenopus laevis Q75WS4 523 60626 P470 L S L G E T Y P Y P I V M A P
Zebra Danio Brachydanio rerio Q4KML2 520 59903 T467 A Q V S L N Q T Y P C P I I T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O77059 542 62494 V489 Q Y E C L I G V H Y P E R I I
Honey Bee Apis mellifera NP_001077099 570 65246 V516 N K Y R G N G V S L K G E T V
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_785873 516 59965 W463 S K Y I F E P W T A P I E V Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q96524 612 69439 G519 A N T I K E P G L C P S V S S
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 98.8 96.4 N.A. 94.5 93.7 N.A. 88.1 85.8 23.4 25.6 N.A. 37.4 62.3 N.A. 57.6
Protein Similarity: 100 99.6 99.4 97.4 N.A. 96.2 95.7 N.A. 90.8 91 40.9 42.5 N.A. 53.2 74.5 N.A. 69.1
P-Site Identity: 100 100 93.3 86.6 N.A. 86.6 86.6 N.A. 33.3 33.3 0 0 N.A. 0 6.6 N.A. 20
P-Site Similarity: 100 100 100 93.3 N.A. 93.3 93.3 N.A. 33.3 46.6 6.6 13.3 N.A. 13.3 33.3 N.A. 40
Percent
Protein Identity: N.A. N.A. N.A. 25.9 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 44.6 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 20 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 46.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 15 0 8 8 50 0 0 8 0 8 0 43 0 8 0 % A
% Cys: 0 0 0 8 0 0 0 0 0 8 8 0 0 0 0 % C
% Asp: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 8 0 8 65 0 0 0 0 0 8 15 0 0 % E
% Phe: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 8 0 8 8 0 15 29 0 15 0 15 43 8 0 % G
% His: 0 36 0 0 0 0 0 0 8 0 0 0 0 0 0 % H
% Ile: 0 0 0 15 0 8 0 0 0 0 8 8 8 15 22 % I
% Lys: 0 15 0 0 8 0 0 0 0 0 8 0 0 0 0 % K
% Leu: 8 0 8 0 15 0 0 0 15 8 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 22 % M
% Asn: 8 15 0 0 0 15 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 50 0 0 0 58 8 8 15 22 8 0 0 8 % P
% Gln: 8 8 0 0 0 0 8 0 0 0 58 0 0 0 8 % Q
% Arg: 0 0 0 8 0 0 0 0 0 0 0 0 8 0 0 % R
% Ser: 65 15 0 8 0 0 15 29 50 43 0 8 15 58 15 % S
% Thr: 0 0 8 0 8 8 0 8 8 0 0 8 0 8 15 % T
% Val: 0 0 8 50 0 0 0 15 0 0 0 8 8 8 15 % V
% Trp: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % W
% Tyr: 0 8 15 0 0 0 8 0 15 8 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _