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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CRY2 All Species: 25.45
Human Site: S543 Identified Species: 43.08
UniProt: Q49AN0 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q49AN0 NP_001120929.1 593 66947 S543 P S S S Q A G S M S S A G P R
Chimpanzee Pan troglodytes XP_001160595 593 66872 S543 P S S S Q A G S M S S A G P R
Rhesus Macaque Macaca mulatta XP_001113162 593 66839 S543 P S S S Q A G S V N S A G P R
Dog Lupus familis XP_540761 593 66822 S543 P S S S Q T G S M S S A G P R
Cat Felis silvestris
Mouse Mus musculus Q9R194 592 66832 S542 P G S S Q A G S I S N T G P R
Rat Rattus norvegicus Q923I8 594 67204 S542 P G S S Q A G S I S N T G P R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507425 582 65716 G530 S G L G Q A S G S N I S T G G
Chicken Gallus gallus Q8QG60 582 66078 S533 S A P G Q G S S T S T A V R L
Frog Xenopus laevis Q75WS4 523 60626 A476 Y P Y P I V M A P E W S R H I
Zebra Danio Brachydanio rerio Q4KML2 520 59903 I473 Q T Y P C P I I T A P E W S R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O77059 542 62494 I495 G V H Y P E R I I D L S M A V
Honey Bee Apis mellifera NP_001077099 570 65246 T522 G V S L K G E T V G L L N A L
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_785873 516 59965 V469 P W T A P I E V Q E K A K C I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q96524 612 69439 S525 P G L C P S V S S N D Q Q V P
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 98.8 96.4 N.A. 94.5 93.7 N.A. 88.1 85.8 23.4 25.6 N.A. 37.4 62.3 N.A. 57.6
Protein Similarity: 100 99.6 99.4 97.4 N.A. 96.2 95.7 N.A. 90.8 91 40.9 42.5 N.A. 53.2 74.5 N.A. 69.1
P-Site Identity: 100 100 86.6 93.3 N.A. 73.3 73.3 N.A. 13.3 26.6 0 6.6 N.A. 0 6.6 N.A. 13.3
P-Site Similarity: 100 100 100 93.3 N.A. 86.6 86.6 N.A. 26.6 40 13.3 20 N.A. 13.3 26.6 N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. 25.9 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 44.6 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 8 0 43 0 8 0 8 0 43 0 15 0 % A
% Cys: 0 0 0 8 8 0 0 0 0 0 0 0 0 8 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 8 8 0 0 0 0 % D
% Glu: 0 0 0 0 0 8 15 0 0 15 0 8 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 15 29 0 15 0 15 43 8 0 8 0 0 43 8 8 % G
% His: 0 0 8 0 0 0 0 0 0 0 0 0 0 8 0 % H
% Ile: 0 0 0 0 8 8 8 15 22 0 8 0 0 0 15 % I
% Lys: 0 0 0 0 8 0 0 0 0 0 8 0 8 0 0 % K
% Leu: 0 0 15 8 0 0 0 0 0 0 15 8 0 0 15 % L
% Met: 0 0 0 0 0 0 8 0 22 0 0 0 8 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 22 15 0 8 0 0 % N
% Pro: 58 8 8 15 22 8 0 0 8 0 8 0 0 43 8 % P
% Gln: 8 0 0 0 58 0 0 0 8 0 0 8 8 0 0 % Q
% Arg: 0 0 0 0 0 0 8 0 0 0 0 0 8 8 50 % R
% Ser: 15 29 50 43 0 8 15 58 15 43 29 22 0 8 0 % S
% Thr: 0 8 8 0 0 8 0 8 15 0 8 15 8 0 0 % T
% Val: 0 15 0 0 0 8 8 8 15 0 0 0 8 8 8 % V
% Trp: 0 8 0 0 0 0 0 0 0 0 8 0 8 0 0 % W
% Tyr: 8 0 15 8 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _