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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PREPL
All Species:
25.15
Human Site:
T541
Identified Species:
50.3
UniProt:
Q4J6C6
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q4J6C6
NP_001035844.1
727
83927
T541
D
L
E
A
C
I
K
T
L
H
G
Q
G
F
S
Chimpanzee
Pan troglodytes
XP_001144400
727
83999
T541
D
L
E
A
C
I
K
T
L
H
G
Q
G
F
S
Rhesus Macaque
Macaca mulatta
XP_001111959
727
83985
T541
D
L
E
A
C
I
K
T
L
H
G
Q
G
F
S
Dog
Lupus familis
XP_531803
727
83861
T541
D
L
E
A
C
I
K
T
L
H
G
Q
G
F
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8C167
725
83176
T539
D
L
V
A
C
I
K
T
L
H
S
Q
G
F
S
Rat
Rattus norvegicus
Q5HZA6
726
83463
T540
D
L
E
A
C
I
K
T
L
H
S
Q
G
F
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521562
342
37329
A160
E
P
R
R
T
A
L
A
A
S
S
A
G
G
L
Chicken
Gallus gallus
Q5ZKL5
732
84295
K546
G
C
Q
Q
N
K
L
K
G
L
H
D
L
K
A
Frog
Xenopus laevis
Q32N48
707
80150
H520
D
L
G
S
C
I
S
H
L
H
G
L
G
Y
S
Zebra Danio
Brachydanio rerio
NP_001139088
692
78210
T506
D
L
A
A
C
I
Q
T
L
H
R
L
G
V
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780381
720
80994
F536
D
L
E
S
C
V
E
F
L
H
S
S
G
F
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001151599
784
87028
H600
G
T
K
A
N
K
M
H
S
I
Q
D
F
A
A
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99
96.1
N.A.
90.9
90.3
N.A.
26.5
47.5
42
37.9
N.A.
N.A.
N.A.
N.A.
29.3
Protein Similarity:
100
99.7
99.5
98.3
N.A.
95
94.7
N.A.
34.5
66.6
61.4
54.8
N.A.
N.A.
N.A.
N.A.
51.4
P-Site Identity:
100
100
100
100
N.A.
86.6
93.3
N.A.
6.6
0
60
66.6
N.A.
N.A.
N.A.
N.A.
60
P-Site Similarity:
100
100
100
100
N.A.
86.6
93.3
N.A.
13.3
13.3
73.3
73.3
N.A.
N.A.
N.A.
N.A.
80
Percent
Protein Identity:
N.A.
26.7
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
46.1
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
20
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
67
0
9
0
9
9
0
0
9
0
9
17
% A
% Cys:
0
9
0
0
75
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
75
0
0
0
0
0
0
0
0
0
0
17
0
0
0
% D
% Glu:
9
0
50
0
0
0
9
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
9
0
0
0
0
9
59
0
% F
% Gly:
17
0
9
0
0
0
0
0
9
0
42
0
84
9
0
% G
% His:
0
0
0
0
0
0
0
17
0
75
9
0
0
0
0
% H
% Ile:
0
0
0
0
0
67
0
0
0
9
0
0
0
0
0
% I
% Lys:
0
0
9
0
0
17
50
9
0
0
0
0
0
9
0
% K
% Leu:
0
75
0
0
0
0
17
0
75
9
0
17
9
0
9
% L
% Met:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
17
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
9
9
0
0
9
0
0
0
9
50
0
0
0
% Q
% Arg:
0
0
9
9
0
0
0
0
0
0
9
0
0
0
0
% R
% Ser:
0
0
0
17
0
0
9
0
9
9
34
9
0
0
75
% S
% Thr:
0
9
0
0
9
0
0
59
0
0
0
0
0
0
0
% T
% Val:
0
0
9
0
0
9
0
0
0
0
0
0
0
9
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _