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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PREPL
All Species:
23.94
Human Site:
Y418
Identified Species:
47.88
UniProt:
Q4J6C6
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q4J6C6
NP_001035844.1
727
83927
Y418
P
I
R
P
P
K
Y
Y
T
Y
K
F
A
E
G
Chimpanzee
Pan troglodytes
XP_001144400
727
83999
Y418
P
I
R
P
P
K
Y
Y
T
Y
K
F
A
E
G
Rhesus Macaque
Macaca mulatta
XP_001111959
727
83985
Y418
P
I
R
P
P
K
Y
Y
T
Y
K
F
A
E
G
Dog
Lupus familis
XP_531803
727
83861
Y418
P
I
R
P
P
K
Y
Y
T
Y
K
F
A
E
G
Cat
Felis silvestris
Mouse
Mus musculus
Q8C167
725
83176
Y416
P
I
R
P
P
K
Y
Y
T
Y
K
F
A
E
G
Rat
Rattus norvegicus
Q5HZA6
726
83463
Y417
P
I
R
P
P
K
Y
Y
T
Y
K
F
A
E
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521562
342
37329
E51
R
Y
R
V
G
R
F
E
A
K
S
K
D
G
T
Chicken
Gallus gallus
Q5ZKL5
732
84295
F434
P
V
H
P
P
R
R
F
A
Y
S
F
K
E
N
Frog
Xenopus laevis
Q32N48
707
80150
F397
P
V
H
P
P
V
H
F
E
Y
S
L
R
K
K
Zebra Danio
Brachydanio rerio
NP_001139088
692
78210
S397
K
L
S
I
T
E
D
S
I
K
H
I
S
I
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780381
720
80994
S413
E
S
D
E
D
T
G
S
G
S
E
D
E
I
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001151599
784
87028
V490
G
L
G
F
Q
S
N
V
S
S
I
Q
Q
N
M
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99
96.1
N.A.
90.9
90.3
N.A.
26.5
47.5
42
37.9
N.A.
N.A.
N.A.
N.A.
29.3
Protein Similarity:
100
99.7
99.5
98.3
N.A.
95
94.7
N.A.
34.5
66.6
61.4
54.8
N.A.
N.A.
N.A.
N.A.
51.4
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
6.6
40
26.6
0
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
20
60
53.3
20
N.A.
N.A.
N.A.
N.A.
6.6
Percent
Protein Identity:
N.A.
26.7
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
46.1
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
0
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
17
0
0
0
50
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
9
0
9
0
9
0
0
0
0
9
9
0
0
% D
% Glu:
9
0
0
9
0
9
0
9
9
0
9
0
9
59
0
% E
% Phe:
0
0
0
9
0
0
9
17
0
0
0
59
0
0
0
% F
% Gly:
9
0
9
0
9
0
9
0
9
0
0
0
0
9
50
% G
% His:
0
0
17
0
0
0
9
0
0
0
9
0
0
0
0
% H
% Ile:
0
50
0
9
0
0
0
0
9
0
9
9
0
17
0
% I
% Lys:
9
0
0
0
0
50
0
0
0
17
50
9
9
9
9
% K
% Leu:
0
17
0
0
0
0
0
0
0
0
0
9
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% M
% Asn:
0
0
0
0
0
0
9
0
0
0
0
0
0
9
9
% N
% Pro:
67
0
0
67
67
0
0
0
0
0
0
0
0
0
9
% P
% Gln:
0
0
0
0
9
0
0
0
0
0
0
9
9
0
9
% Q
% Arg:
9
0
59
0
0
17
9
0
0
0
0
0
9
0
0
% R
% Ser:
0
9
9
0
0
9
0
17
9
17
25
0
9
0
0
% S
% Thr:
0
0
0
0
9
9
0
0
50
0
0
0
0
0
9
% T
% Val:
0
17
0
9
0
9
0
9
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
9
0
0
0
0
50
50
0
67
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _