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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: AASDH All Species: 1.52
Human Site: S592 Identified Species: 2.78
UniProt: Q4L235 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q4L235 NP_861522.2 1098 122597 S592 S G G D S L K S I R L L S E I
Chimpanzee Pan troglodytes XP_526619 419 46896
Rhesus Macaque Macaca mulatta XP_001084597 517 57678 E14 F V T V K D G E I F F L G R K
Dog Lupus familis XP_539278 1094 122201 K588 N S G G D S L K S I R L L N E
Cat Felis silvestris
Mouse Mus musculus Q80WC9 1100 121551 S591 F L D S G G D S L K S M R L L
Rat Rattus norvegicus XP_344231 1099 121246 L590 L D S G G D S L K S L W L L G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521114 1121 120374 W612 L R G E E Q L W E R L Q D I W
Chicken Gallus gallus XP_420697 1128 125269 G615 I E M L V G R G V P G L L E V
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q5RG49 1149 125488 V624 V A M G T T S V G L L E V I L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VLL0 1012 113065 F509 R F V Y L Q H F P C N V H G K
Honey Bee Apis mellifera XP_395233 653 74131 E150 R A I L F G G E P F P K L E V
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002325887 1058 116913 L554 S K L H A A L L E K K E S Y C
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_198442 1040 115575 I536 H L S H S L G I D M R L I Y Q
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 37.4 44.9 85.4 N.A. 72.8 71.8 N.A. 53.8 57.4 N.A. 41.9 N.A. 24.2 23.1 N.A. N.A.
Protein Similarity: 100 37.7 45.8 91.5 N.A. 84.4 83.7 N.A. 69.5 73.4 N.A. 60.1 N.A. 44.6 38.7 N.A. N.A.
P-Site Identity: 100 0 13.3 13.3 N.A. 6.6 6.6 N.A. 20 13.3 N.A. 6.6 N.A. 0 6.6 N.A. N.A.
P-Site Similarity: 100 0 13.3 20 N.A. 33.3 6.6 N.A. 26.6 33.3 N.A. 20 N.A. 6.6 13.3 N.A. N.A.
Percent
Protein Identity: 22.7 N.A. N.A. 24.1 N.A. N.A.
Protein Similarity: 43.1 N.A. N.A. 42.7 N.A. N.A.
P-Site Identity: 13.3 N.A. N.A. 20 N.A. N.A.
P-Site Similarity: 26.6 N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 16 0 0 8 8 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 8 % C
% Asp: 0 8 8 8 8 16 8 0 8 0 0 0 8 0 0 % D
% Glu: 0 8 0 8 8 0 0 16 16 0 0 16 0 24 8 % E
% Phe: 16 8 0 0 8 0 0 8 0 16 8 0 0 0 0 % F
% Gly: 0 8 24 24 16 24 24 8 8 0 8 0 8 8 8 % G
% His: 8 0 0 16 0 0 8 0 0 0 0 0 8 0 0 % H
% Ile: 8 0 8 0 0 0 0 8 16 8 0 0 8 16 8 % I
% Lys: 0 8 0 0 8 0 8 8 8 16 8 8 0 0 16 % K
% Leu: 16 16 8 16 8 16 24 16 8 8 31 39 31 16 16 % L
% Met: 0 0 16 0 0 0 0 0 0 8 0 8 0 0 0 % M
% Asn: 8 0 0 0 0 0 0 0 0 0 8 0 0 8 0 % N
% Pro: 0 0 0 0 0 0 0 0 16 8 8 0 0 0 0 % P
% Gln: 0 0 0 0 0 16 0 0 0 0 0 8 0 0 8 % Q
% Arg: 16 8 0 0 0 0 8 0 0 16 16 0 8 8 0 % R
% Ser: 16 8 16 8 16 8 16 16 8 8 8 0 16 0 0 % S
% Thr: 0 0 8 0 8 8 0 0 0 0 0 0 0 0 0 % T
% Val: 8 8 8 8 8 0 0 8 8 0 0 8 8 0 16 % V
% Trp: 0 0 0 0 0 0 0 8 0 0 0 8 0 0 8 % W
% Tyr: 0 0 0 8 0 0 0 0 0 0 0 0 0 16 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _