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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: AASDH All Species: 0.61
Human Site: S641 Identified Species: 1.11
UniProt: Q4L235 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q4L235 NP_861522.2 1098 122597 S641 E D V T F R K S C A T K R K L
Chimpanzee Pan troglodytes XP_526619 419 46896
Rhesus Macaque Macaca mulatta XP_001084597 517 57678 F63 N Q E K L I L F M V S K D A S
Dog Lupus familis XP_539278 1094 122201 K637 D E D L V F S K N Y A T K R K
Cat Felis silvestris
Mouse Mus musculus Q80WC9 1100 121551 A640 F T P E D R K A N R S Y T T K
Rat Rattus norvegicus XP_344231 1099 121246 D639 T R E D L K G D R R Y T T K R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521114 1121 120374 T661 E V E G L V G T A V P G L L E
Chicken Gallus gallus XP_420697 1128 125269 E664 L S K N N G E E I H R K Y A K
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q5RG49 1149 125488 K673 A S G K R Q H K E M T T S S D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VLL0 1012 113065 K558 P D D S A S K K Q R L D D A A
Honey Bee Apis mellifera XP_395233 653 74131 Y199 G G Q F N V H Y L G Q V L S H
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002325887 1058 116913 P603 G L K S M K Q P S K N P H Q N
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_198442 1040 115575 L585 E S Q N G N G L V S R T V P L
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 37.4 44.9 85.4 N.A. 72.8 71.8 N.A. 53.8 57.4 N.A. 41.9 N.A. 24.2 23.1 N.A. N.A.
Protein Similarity: 100 37.7 45.8 91.5 N.A. 84.4 83.7 N.A. 69.5 73.4 N.A. 60.1 N.A. 44.6 38.7 N.A. N.A.
P-Site Identity: 100 0 6.6 0 N.A. 13.3 6.6 N.A. 6.6 6.6 N.A. 6.6 N.A. 13.3 0 N.A. N.A.
P-Site Similarity: 100 0 13.3 26.6 N.A. 26.6 13.3 N.A. 13.3 13.3 N.A. 13.3 N.A. 20 0 N.A. N.A.
Percent
Protein Identity: 22.7 N.A. N.A. 24.1 N.A. N.A.
Protein Similarity: 43.1 N.A. N.A. 42.7 N.A. N.A.
P-Site Identity: 0 N.A. N.A. 13.3 N.A. N.A.
P-Site Similarity: 26.6 N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 0 8 0 0 8 8 8 8 0 0 24 8 % A
% Cys: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % C
% Asp: 8 16 16 8 8 0 0 8 0 0 0 8 16 0 8 % D
% Glu: 24 8 24 8 0 0 8 8 8 0 0 0 0 0 8 % E
% Phe: 8 0 0 8 8 8 0 8 0 0 0 0 0 0 0 % F
% Gly: 16 8 8 8 8 8 24 0 0 8 0 8 0 0 0 % G
% His: 0 0 0 0 0 0 16 0 0 8 0 0 8 0 8 % H
% Ile: 0 0 0 0 0 8 0 0 8 0 0 0 0 0 0 % I
% Lys: 0 0 16 16 0 16 24 24 0 8 0 24 8 16 24 % K
% Leu: 8 8 0 8 24 0 8 8 8 0 8 0 16 8 16 % L
% Met: 0 0 0 0 8 0 0 0 8 8 0 0 0 0 0 % M
% Asn: 8 0 0 16 16 8 0 0 16 0 8 0 0 0 8 % N
% Pro: 8 0 8 0 0 0 0 8 0 0 8 8 0 8 0 % P
% Gln: 0 8 16 0 0 8 8 0 8 0 8 0 0 8 0 % Q
% Arg: 0 8 0 0 8 16 0 0 8 24 16 0 8 8 8 % R
% Ser: 0 24 0 16 0 8 8 8 8 8 16 0 8 16 8 % S
% Thr: 8 8 0 8 0 0 0 8 0 0 16 31 16 8 0 % T
% Val: 0 8 8 0 8 16 0 0 8 16 0 8 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 8 0 8 8 8 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _