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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: AASDH All Species: 3.33
Human Site: S703 Identified Species: 6.11
UniProt: Q4L235 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q4L235 NP_861522.2 1098 122597 S703 L T K L G H C S S A C P S D S
Chimpanzee Pan troglodytes XP_526619 419 46896 R27 R K D S Q I K R H G K R L N I
Rhesus Macaque Macaca mulatta XP_001084597 517 57678 N125 Y I N L K S E N K L S G K E D
Dog Lupus familis XP_539278 1094 122201 S699 L T K L G L C S S A Q S S D L
Cat Felis silvestris
Mouse Mus musculus Q80WC9 1100 121551 G702 G R L L T Q L G L C L P V C S
Rat Rattus norvegicus XP_344231 1099 121246 L701 R L L T E L G L C P N A V H P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521114 1121 120374 G723 P E P G R P G G A D P G P E P
Chicken Gallus gallus XP_420697 1128 125269 H726 L Q Q P S F L H A V T P S I T
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q5RG49 1149 125488 D735 T N N S V G N D T G L I S N P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VLL0 1012 113065 F620 P L R T V L R F L D T A K L V
Honey Bee Apis mellifera XP_395233 653 74131 E261 G D I V D I N E E G K I F Y K
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002325887 1058 116913 R665 V I Y D E N C R S R K S H Q I
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_198442 1040 115575 R647 Q I Q C A F S R C N K V H S P
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 37.4 44.9 85.4 N.A. 72.8 71.8 N.A. 53.8 57.4 N.A. 41.9 N.A. 24.2 23.1 N.A. N.A.
Protein Similarity: 100 37.7 45.8 91.5 N.A. 84.4 83.7 N.A. 69.5 73.4 N.A. 60.1 N.A. 44.6 38.7 N.A. N.A.
P-Site Identity: 100 0 6.6 73.3 N.A. 20 0 N.A. 0 20 N.A. 6.6 N.A. 0 0 N.A. N.A.
P-Site Similarity: 100 6.6 20 73.3 N.A. 20 0 N.A. 13.3 40 N.A. 20 N.A. 6.6 6.6 N.A. N.A.
Percent
Protein Identity: 22.7 N.A. N.A. 24.1 N.A. N.A.
Protein Similarity: 43.1 N.A. N.A. 42.7 N.A. N.A.
P-Site Identity: 13.3 N.A. N.A. 0 N.A. N.A.
P-Site Similarity: 26.6 N.A. N.A. 6.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 8 0 0 0 16 16 0 16 0 0 0 % A
% Cys: 0 0 0 8 0 0 24 0 16 8 8 0 0 8 0 % C
% Asp: 0 8 8 8 8 0 0 8 0 16 0 0 0 16 8 % D
% Glu: 0 8 0 0 16 0 8 8 8 0 0 0 0 16 0 % E
% Phe: 0 0 0 0 0 16 0 8 0 0 0 0 8 0 0 % F
% Gly: 16 0 0 8 16 8 16 16 0 24 0 16 0 0 0 % G
% His: 0 0 0 0 0 8 0 8 8 0 0 0 16 8 0 % H
% Ile: 0 24 8 0 0 16 0 0 0 0 0 16 0 8 16 % I
% Lys: 0 8 16 0 8 0 8 0 8 0 31 0 16 0 8 % K
% Leu: 24 16 16 31 0 24 16 8 16 8 16 0 8 8 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 8 16 0 0 8 16 8 0 8 8 0 0 16 0 % N
% Pro: 16 0 8 8 0 8 0 0 0 8 8 24 8 0 31 % P
% Gln: 8 8 16 0 8 8 0 0 0 0 8 0 0 8 0 % Q
% Arg: 16 8 8 0 8 0 8 24 0 8 0 8 0 0 0 % R
% Ser: 0 0 0 16 8 8 8 16 24 0 8 16 31 8 16 % S
% Thr: 8 16 0 16 8 0 0 0 8 0 16 0 0 0 8 % T
% Val: 8 0 0 8 16 0 0 0 0 8 0 8 16 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 8 0 0 0 0 0 0 0 0 0 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _