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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: AASDH All Species: 4.85
Human Site: S724 Identified Species: 8.89
UniProt: Q4L235 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q4L235 NP_861522.2 1098 122597 S724 Q N L K G L N S P V L I G K S
Chimpanzee Pan troglodytes XP_526619 419 46896 E48 A E E L Q Q V E S C A V T W Y
Rhesus Macaque Macaca mulatta XP_001084597 517 57678 N146 Y L W K S T L N L S E D L L K
Dog Lupus familis XP_539278 1094 122201 P720 Q N V K S L N P P A L I G K S
Cat Felis silvestris
Mouse Mus musculus Q80WC9 1100 121551 S723 T N T Q I L K S L S P P A P D
Rat Rattus norvegicus XP_344231 1099 121246 S722 T N T E I L K S L S P P A L D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521114 1121 120374 V744 D P E P A T F V A V S R G S Q
Chicken Gallus gallus XP_420697 1128 125269 L747 Y E K E N R T L T I T N E V N
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q5RG49 1149 125488 A756 S S A V T N M A D H L Q A Q E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VLL0 1012 113065 V641 K N V E T A V V V S A C Q S G
Honey Bee Apis mellifera XP_395233 653 74131 V282 I K R F G N K V D L T K L K E
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002325887 1058 116913 S686 P R N G K G S S M H E L W K V
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_198442 1040 115575 S668 E A N R E Y W S L E I P R N Q
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 37.4 44.9 85.4 N.A. 72.8 71.8 N.A. 53.8 57.4 N.A. 41.9 N.A. 24.2 23.1 N.A. N.A.
Protein Similarity: 100 37.7 45.8 91.5 N.A. 84.4 83.7 N.A. 69.5 73.4 N.A. 60.1 N.A. 44.6 38.7 N.A. N.A.
P-Site Identity: 100 0 6.6 73.3 N.A. 20 20 N.A. 13.3 0 N.A. 6.6 N.A. 6.6 13.3 N.A. N.A.
P-Site Similarity: 100 6.6 13.3 80 N.A. 26.6 26.6 N.A. 13.3 20 N.A. 26.6 N.A. 26.6 20 N.A. N.A.
Percent
Protein Identity: 22.7 N.A. N.A. 24.1 N.A. N.A.
Protein Similarity: 43.1 N.A. N.A. 42.7 N.A. N.A.
P-Site Identity: 13.3 N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: 26.6 N.A. N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 8 0 8 8 0 8 8 8 16 0 24 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 8 0 8 0 0 0 % C
% Asp: 8 0 0 0 0 0 0 0 16 0 0 8 0 0 16 % D
% Glu: 8 16 16 24 8 0 0 8 0 8 16 0 8 0 16 % E
% Phe: 0 0 0 8 0 0 8 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 8 16 8 0 0 0 0 0 0 24 0 8 % G
% His: 0 0 0 0 0 0 0 0 0 16 0 0 0 0 0 % H
% Ile: 8 0 0 0 16 0 0 0 0 8 8 16 0 0 0 % I
% Lys: 8 8 8 24 8 0 24 0 0 0 0 8 0 31 8 % K
% Leu: 0 8 8 8 0 31 8 8 31 8 24 8 16 16 0 % L
% Met: 0 0 0 0 0 0 8 0 8 0 0 0 0 0 0 % M
% Asn: 0 39 16 0 8 16 16 8 0 0 0 8 0 8 8 % N
% Pro: 8 8 0 8 0 0 0 8 16 0 16 24 0 8 0 % P
% Gln: 16 0 0 8 8 8 0 0 0 0 0 8 8 8 16 % Q
% Arg: 0 8 8 8 0 8 0 0 0 0 0 8 8 0 0 % R
% Ser: 8 8 0 0 16 0 8 39 8 31 8 0 0 16 16 % S
% Thr: 16 0 16 0 16 16 8 0 8 0 16 0 8 0 0 % T
% Val: 0 0 16 8 0 0 16 24 8 16 0 8 0 8 8 % V
% Trp: 0 0 8 0 0 0 8 0 0 0 0 0 8 8 0 % W
% Tyr: 16 0 0 0 0 8 0 0 0 0 0 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _