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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: AASDH All Species: 23.64
Human Site: S841 Identified Species: 43.33
UniProt: Q4L235 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q4L235 NP_861522.2 1098 122597 S841 G L V Y V L K S N S G E K Y W
Chimpanzee Pan troglodytes XP_526619 419 46896 G165 S L F L N S G G D S L K S I R
Rhesus Macaque Macaca mulatta XP_001084597 517 57678 S263 F V A L S R G S Q I L S L N T
Dog Lupus familis XP_539278 1094 122201 S837 G L V Y V L K S N S G E K Y W
Cat Felis silvestris
Mouse Mus musculus Q80WC9 1100 121551 S840 G L V Y V L K S N S G E K Y W
Rat Rattus norvegicus XP_344231 1099 121246 S839 G L V Y V L K S N S G E K H W
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521114 1121 120374 S861 G F V Y V L R S A T G E T H W
Chicken Gallus gallus XP_420697 1128 125269 S864 G L V Y V L Q S S D G E A Y W
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q5RG49 1149 125488 V873 R Q M Y F L D V S C G D T V W
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VLL0 1012 113065 Q758 I G G L I K S Q P M L T A D G
Honey Bee Apis mellifera XP_395233 653 74131 N399 N A M S E I S N I E F P K L I
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002325887 1058 116913 H803 Q L I W C G S H D H N L Y A L
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_198442 1040 115575 T785 K C Q P V V D T S S Q L I W C
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 37.4 44.9 85.4 N.A. 72.8 71.8 N.A. 53.8 57.4 N.A. 41.9 N.A. 24.2 23.1 N.A. N.A.
Protein Similarity: 100 37.7 45.8 91.5 N.A. 84.4 83.7 N.A. 69.5 73.4 N.A. 60.1 N.A. 44.6 38.7 N.A. N.A.
P-Site Identity: 100 13.3 6.6 100 N.A. 100 93.3 N.A. 60 73.3 N.A. 26.6 N.A. 0 6.6 N.A. N.A.
P-Site Similarity: 100 26.6 13.3 100 N.A. 100 100 N.A. 80 86.6 N.A. 46.6 N.A. 6.6 26.6 N.A. N.A.
Percent
Protein Identity: 22.7 N.A. N.A. 24.1 N.A. N.A.
Protein Similarity: 43.1 N.A. N.A. 42.7 N.A. N.A.
P-Site Identity: 6.6 N.A. N.A. 13.3 N.A. N.A.
P-Site Similarity: 26.6 N.A. N.A. 40 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 8 0 0 0 0 0 8 0 0 0 16 8 0 % A
% Cys: 0 8 0 0 8 0 0 0 0 8 0 0 0 0 8 % C
% Asp: 0 0 0 0 0 0 16 0 16 8 0 8 0 8 0 % D
% Glu: 0 0 0 0 8 0 0 0 0 8 0 47 0 0 0 % E
% Phe: 8 8 8 0 8 0 0 0 0 0 8 0 0 0 0 % F
% Gly: 47 8 8 0 0 8 16 8 0 0 54 0 0 0 8 % G
% His: 0 0 0 0 0 0 0 8 0 8 0 0 0 16 0 % H
% Ile: 8 0 8 0 8 8 0 0 8 8 0 0 8 8 8 % I
% Lys: 8 0 0 0 0 8 31 0 0 0 0 8 39 0 0 % K
% Leu: 0 54 0 24 0 54 0 0 0 0 24 16 8 8 8 % L
% Met: 0 0 16 0 0 0 0 0 0 8 0 0 0 0 0 % M
% Asn: 8 0 0 0 8 0 0 8 31 0 8 0 0 8 0 % N
% Pro: 0 0 0 8 0 0 0 0 8 0 0 8 0 0 0 % P
% Gln: 8 8 8 0 0 0 8 8 8 0 8 0 0 0 0 % Q
% Arg: 8 0 0 0 0 8 8 0 0 0 0 0 0 0 8 % R
% Ser: 8 0 0 8 8 8 24 54 24 47 0 8 8 0 0 % S
% Thr: 0 0 0 0 0 0 0 8 0 8 0 8 16 0 8 % T
% Val: 0 8 47 0 54 8 0 8 0 0 0 0 0 8 0 % V
% Trp: 0 0 0 8 0 0 0 0 0 0 0 0 0 8 54 % W
% Tyr: 0 0 0 54 0 0 0 0 0 0 0 0 8 31 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _