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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: AASDH All Species: 8.79
Human Site: S95 Identified Species: 16.11
UniProt: Q4L235 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q4L235 NP_861522.2 1098 122597 S95 I E P D S P P S L S T H F M K
Chimpanzee Pan troglodytes XP_526619 419 46896
Rhesus Macaque Macaca mulatta XP_001084597 517 57678
Dog Lupus familis XP_539278 1094 122201 A95 I D P D S P P A L S T H F M K
Cat Felis silvestris
Mouse Mus musculus Q80WC9 1100 121551 S95 I D P D S P P S L S T Y F M K
Rat Rattus norvegicus XP_344231 1099 121246 S95 I D P D S L P S L A T H F M K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521114 1121 120374 V150 I D P D A P T V Y S A Y F M R
Chicken Gallus gallus XP_420697 1128 125269 L95 I D P D A P P L L S A Y F M R
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q5RG49 1149 125488 P94 L P L D P A S P P Q C S L R M
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VLL0 1012 113065 A48 K D T I V S Y A D A A D E I Q
Honey Bee Apis mellifera XP_395233 653 74131
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002325887 1058 116913 L91 C S G G P S E L A W P C E N E
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_198442 1040 115575 L75 E R N V C P V L L F S M D E K
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 37.4 44.9 85.4 N.A. 72.8 71.8 N.A. 53.8 57.4 N.A. 41.9 N.A. 24.2 23.1 N.A. N.A.
Protein Similarity: 100 37.7 45.8 91.5 N.A. 84.4 83.7 N.A. 69.5 73.4 N.A. 60.1 N.A. 44.6 38.7 N.A. N.A.
P-Site Identity: 100 0 0 86.6 N.A. 86.6 80 N.A. 46.6 60 N.A. 6.6 N.A. 0 0 N.A. N.A.
P-Site Similarity: 100 0 0 100 N.A. 100 93.3 N.A. 73.3 86.6 N.A. 13.3 N.A. 33.3 0 N.A. N.A.
Percent
Protein Identity: 22.7 N.A. N.A. 24.1 N.A. N.A.
Protein Similarity: 43.1 N.A. N.A. 42.7 N.A. N.A.
P-Site Identity: 0 N.A. N.A. 20 N.A. N.A.
P-Site Similarity: 6.6 N.A. N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 16 8 0 16 8 16 24 0 0 0 0 % A
% Cys: 8 0 0 0 8 0 0 0 0 0 8 8 0 0 0 % C
% Asp: 0 47 0 54 0 0 0 0 8 0 0 8 8 0 0 % D
% Glu: 8 8 0 0 0 0 8 0 0 0 0 0 16 8 8 % E
% Phe: 0 0 0 0 0 0 0 0 0 8 0 0 47 0 0 % F
% Gly: 0 0 8 8 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 24 0 0 0 % H
% Ile: 47 0 0 8 0 0 0 0 0 0 0 0 0 8 0 % I
% Lys: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 39 % K
% Leu: 8 0 8 0 0 8 0 24 47 0 0 0 8 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 8 0 47 8 % M
% Asn: 0 0 8 0 0 0 0 0 0 0 0 0 0 8 0 % N
% Pro: 0 8 47 0 16 47 39 8 8 0 8 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 8 % Q
% Arg: 0 8 0 0 0 0 0 0 0 0 0 0 0 8 16 % R
% Ser: 0 8 0 0 31 16 8 24 0 39 8 8 0 0 0 % S
% Thr: 0 0 8 0 0 0 8 0 0 0 31 0 0 0 0 % T
% Val: 0 0 0 8 8 0 8 8 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 8 0 8 0 0 24 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _