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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: AASDH All Species: 14.24
Human Site: T326 Identified Species: 26.11
UniProt: Q4L235 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q4L235 NP_861522.2 1098 122597 T326 G E A F P S L T V L R S W R G
Chimpanzee Pan troglodytes XP_526619 419 46896
Rhesus Macaque Macaca mulatta XP_001084597 517 57678
Dog Lupus familis XP_539278 1094 122201 T326 G E A F P S L T V L K S W R G
Cat Felis silvestris
Mouse Mus musculus Q80WC9 1100 121551 T325 G E A F P S L T I L K S W R G
Rat Rattus norvegicus XP_344231 1099 121246 T325 G E A F P S L T V L Q S W R G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521114 1121 120374 L362 R L L K S T A L S A G S P L R
Chicken Gallus gallus XP_420697 1128 125269 N334 G E A F P V L N L W K S W K H
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q5RG49 1149 125488 N306 G E P C P S L N L V K S W R Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VLL0 1012 113065 D259 V L S A L F P D N L A T P G I
Honey Bee Apis mellifera XP_395233 653 74131
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002325887 1058 116913 T302 A L I C E S D T S N E G E I Y
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_198442 1040 115575 P286 T E E I G S V P I G K S I S N
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 37.4 44.9 85.4 N.A. 72.8 71.8 N.A. 53.8 57.4 N.A. 41.9 N.A. 24.2 23.1 N.A. N.A.
Protein Similarity: 100 37.7 45.8 91.5 N.A. 84.4 83.7 N.A. 69.5 73.4 N.A. 60.1 N.A. 44.6 38.7 N.A. N.A.
P-Site Identity: 100 0 0 93.3 N.A. 86.6 93.3 N.A. 6.6 53.3 N.A. 53.3 N.A. 6.6 0 N.A. N.A.
P-Site Similarity: 100 0 0 100 N.A. 100 100 N.A. 13.3 73.3 N.A. 73.3 N.A. 20 0 N.A. N.A.
Percent
Protein Identity: 22.7 N.A. N.A. 24.1 N.A. N.A.
Protein Similarity: 43.1 N.A. N.A. 42.7 N.A. N.A.
P-Site Identity: 13.3 N.A. N.A. 20 N.A. N.A.
P-Site Similarity: 13.3 N.A. N.A. 40 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 39 8 0 0 8 0 0 8 8 0 0 0 0 % A
% Cys: 0 0 0 16 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 8 8 0 0 0 0 0 0 0 % D
% Glu: 0 54 8 0 8 0 0 0 0 0 8 0 8 0 0 % E
% Phe: 0 0 0 39 0 8 0 0 0 0 0 0 0 0 0 % F
% Gly: 47 0 0 0 8 0 0 0 0 8 8 8 0 8 31 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % H
% Ile: 0 0 8 8 0 0 0 0 16 0 0 0 8 8 8 % I
% Lys: 0 0 0 8 0 0 0 0 0 0 39 0 0 8 0 % K
% Leu: 0 24 8 0 8 0 47 8 16 39 0 0 0 8 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 16 8 8 0 0 0 0 8 % N
% Pro: 0 0 8 0 47 0 8 8 0 0 0 0 16 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 8 % Q
% Arg: 8 0 0 0 0 0 0 0 0 0 8 0 0 39 8 % R
% Ser: 0 0 8 0 8 54 0 0 16 0 0 62 0 8 0 % S
% Thr: 8 0 0 0 0 8 0 39 0 0 0 8 0 0 0 % T
% Val: 8 0 0 0 0 8 8 0 24 8 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 8 0 0 47 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _