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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HIGD2B
All Species:
21.52
Human Site:
S25
Identified Species:
39.44
UniProt:
Q4VC39
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q4VC39
NP_620175
106
11405
S25
P
P
I
F
E
G
L
S
P
T
V
Y
S
N
P
Chimpanzee
Pan troglodytes
XP_523210
106
11357
S25
P
P
I
F
E
G
L
S
P
T
V
Y
S
N
P
Rhesus Macaque
Macaca mulatta
XP_001084675
106
11638
S25
P
P
V
I
E
G
L
S
P
T
V
Y
R
D
P
Dog
Lupus familis
XP_536423
106
11321
S25
P
P
V
I
E
G
F
S
P
S
I
Y
S
P
P
Cat
Felis silvestris
Mouse
Mus musculus
Q9CQJ1
106
11350
S25
P
P
V
I
E
G
F
S
P
T
V
Y
S
N
P
Rat
Rattus norvegicus
Q8VH49
93
10283
D13
D
L
S
L
S
S
Y
D
E
G
Q
G
S
K
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514680
81
8548
Chicken
Gallus gallus
XP_414550
124
13681
S43
L
P
R
P
W
S
P
S
R
C
R
C
T
A
D
Frog
Xenopus laevis
NP_001087828
93
10198
T13
I
E
G
F
T
P
S
T
Y
D
S
E
G
F
K
Zebra Danio
Brachydanio rerio
NP_001017641
116
12208
S35
P
P
V
I
E
G
F
S
P
T
S
R
T
R
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_573120
102
11395
D22
D
W
I
Q
L
R
Q
D
L
G
P
V
A
E
V
Honey Bee
Apis mellifera
XP_001122466
103
11799
K23
D
W
I
R
V
Q
T
K
L
N
D
D
Y
K
I
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780376
117
12675
Y31
G
D
I
P
L
E
L
Y
D
W
V
P
A
Q
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.1
71.6
71.6
N.A.
74.5
35.8
N.A.
41.5
41.9
49
49.1
N.A.
40.5
35.8
N.A.
41.8
Protein Similarity:
100
99
82
82
N.A.
83.9
52.8
N.A.
53.7
59.6
63.2
68
N.A.
58.4
53.7
N.A.
55.5
P-Site Identity:
100
100
73.3
60
N.A.
80
6.6
N.A.
0
13.3
6.6
46.6
N.A.
6.6
6.6
N.A.
20
P-Site Similarity:
100
100
86.6
80
N.A.
86.6
6.6
N.A.
0
20
13.3
60
N.A.
13.3
6.6
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
16
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
8
0
8
0
0
0
% C
% Asp:
24
8
0
0
0
0
0
16
8
8
8
8
0
8
8
% D
% Glu:
0
8
0
0
47
8
0
0
8
0
0
8
0
8
8
% E
% Phe:
0
0
0
24
0
0
24
0
0
0
0
0
0
8
8
% F
% Gly:
8
0
8
0
0
47
0
0
0
16
0
8
8
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
39
31
0
0
0
0
0
0
8
0
0
0
8
% I
% Lys:
0
0
0
0
0
0
0
8
0
0
0
0
0
16
8
% K
% Leu:
8
8
0
8
16
0
31
0
16
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
8
0
0
0
24
0
% N
% Pro:
47
54
0
16
0
8
8
0
47
0
8
8
0
8
39
% P
% Gln:
0
0
0
8
0
8
8
0
0
0
8
0
0
8
8
% Q
% Arg:
0
0
8
8
0
8
0
0
8
0
8
8
8
8
0
% R
% Ser:
0
0
8
0
8
16
8
54
0
8
16
0
39
0
0
% S
% Thr:
0
0
0
0
8
0
8
8
0
39
0
0
16
0
0
% T
% Val:
0
0
31
0
8
0
0
0
0
0
39
8
0
0
8
% V
% Trp:
0
16
0
0
8
0
0
0
0
8
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
8
8
8
0
0
39
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _