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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PAN2 All Species: 18.18
Human Site: Y139 Identified Species: 30.77
UniProt: Q504Q3 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q504Q3 NP_001120932.1 1202 135368 Y139 L T K N N L K Y M A R G G L I
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001114958 1201 135190 Y139 L T K N N L K Y M A R G G L I
Dog Lupus familis XP_531635 1201 135014 Y139 L T K N N L K Y M A R G G L I
Cat Felis silvestris
Mouse Mus musculus Q8BGF7 1200 135235 Y139 L T K N N L K Y M A R G G L I
Rat Rattus norvegicus Q6IE70 1205 135608 Y139 L T K N N L K Y M A R G G L I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513697 979 109930 A17 Q A E H E L D A Y S G S L S D
Chicken Gallus gallus Q5F450 1197 134844 C139 L T K T N L K C M S R G G L I
Frog Xenopus laevis NP_001086001 639 71850
Zebra Danio Brachydanio rerio XP_001920000 1198 135304 C139 L T K N N L R C L T R G G F I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_610427 1241 138949 H127 L T Q T S L R H Q I R R G L P
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P53015 1131 127156 H134 G F Q E K L I H Y D F V K E K
Sea Urchin Strong. purpuratus XP_001194902 1068 120683 L106 S T F P G G V L S L Y N N G L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P53010 1115 127021 L127 M C Y S P H S L K N N I Y C G
Red Bread Mold Neurospora crassa P0C581 1236 136082 L130 A G W Q N K M L V I D V N K G
Conservation
Percent
Protein Identity: 100 N.A. 99.2 97.4 N.A. 96 94.6 N.A. 60.1 85.7 43.7 74.1 N.A. 42.2 N.A. 26.7 44.4
Protein Similarity: 100 N.A. 99.7 99.1 N.A. 97.9 96.9 N.A. 68.3 92.7 48.8 86.1 N.A. 59.3 N.A. 45 61.3
P-Site Identity: 100 N.A. 100 100 N.A. 100 100 N.A. 6.6 80 0 66.6 N.A. 40 N.A. 6.6 6.6
P-Site Similarity: 100 N.A. 100 100 N.A. 100 100 N.A. 26.6 86.6 0 80 N.A. 66.6 N.A. 20 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 24.3 22.1
Protein Similarity: N.A. N.A. N.A. N.A. 41.6 41.5
P-Site Identity: N.A. N.A. N.A. N.A. 0 6.6
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 0 0 0 0 0 8 0 36 0 0 0 0 0 % A
% Cys: 0 8 0 0 0 0 0 15 0 0 0 0 0 8 0 % C
% Asp: 0 0 0 0 0 0 8 0 0 8 8 0 0 0 8 % D
% Glu: 0 0 8 8 8 0 0 0 0 0 0 0 0 8 0 % E
% Phe: 0 8 8 0 0 0 0 0 0 0 8 0 0 8 0 % F
% Gly: 8 8 0 0 8 8 0 0 0 0 8 50 58 8 15 % G
% His: 0 0 0 8 0 8 0 15 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 8 0 0 15 0 8 0 0 50 % I
% Lys: 0 0 50 0 8 8 43 0 8 0 0 0 8 8 8 % K
% Leu: 58 0 0 0 0 72 0 22 8 8 0 0 8 50 8 % L
% Met: 8 0 0 0 0 0 8 0 43 0 0 0 0 0 0 % M
% Asn: 0 0 0 43 58 0 0 0 0 8 8 8 15 0 0 % N
% Pro: 0 0 0 8 8 0 0 0 0 0 0 0 0 0 8 % P
% Gln: 8 0 15 8 0 0 0 0 8 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 15 0 0 0 58 8 0 0 0 % R
% Ser: 8 0 0 8 8 0 8 0 8 15 0 8 0 8 0 % S
% Thr: 0 65 0 15 0 0 0 0 0 8 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 8 0 8 0 0 15 0 0 0 % V
% Trp: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 0 0 0 0 36 15 0 8 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _