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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSD17B12
All Species:
13.64
Human Site:
S92
Identified Species:
25
UniProt:
Q53GQ0
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q53GQ0
NP_057226.1
312
34324
S92
D
K
L
D
Q
V
S
S
E
I
K
E
K
F
K
Chimpanzee
Pan troglodytes
XP_001158375
312
34320
S92
D
K
L
D
Q
V
S
S
E
I
K
E
K
F
K
Rhesus Macaque
Macaca mulatta
XP_001113903
312
34903
S92
D
K
L
D
Q
V
S
S
E
I
K
E
K
F
K
Dog
Lupus familis
XP_848504
312
34370
S92
D
K
L
N
Q
V
S
S
E
I
R
E
K
F
K
Cat
Felis silvestris
Mouse
Mus musculus
O70503
312
34723
N92
D
K
L
N
Q
V
S
N
N
I
K
E
K
F
N
Rat
Rattus norvegicus
Q6P7R8
312
34822
N92
D
K
L
K
E
V
S
N
N
I
K
E
K
F
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZJG8
331
37589
R109
E
K
L
E
A
V
S
R
S
I
S
E
T
Y
K
Frog
Xenopus laevis
Q8AVY8
318
34842
I96
E
K
L
E
E
A
A
I
H
I
K
Q
K
F
K
Zebra Danio
Brachydanio rerio
Q6P3L6
319
35532
K98
E
K
L
D
D
V
A
K
S
L
E
S
T
Y
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572420
321
35098
K94
E
K
L
N
V
V
A
K
E
I
G
D
K
Y
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09517
316
34290
K89
S
K
L
D
E
T
K
K
E
I
L
E
K
Y
S
Sea Urchin
Strong. purpuratus
XP_001179990
285
31136
E74
G
I
G
K
A
Y
A
E
Q
L
A
A
K
G
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7RYE5
332
36765
R98
S
K
L
D
V
L
A
R
E
L
E
L
R
W
D
Conservation
Percent
Protein Identity:
100
99.6
85.9
85.5
N.A.
81
81.7
N.A.
N.A.
42.9
61.6
59.2
N.A.
44.2
N.A.
38.6
46.7
Protein Similarity:
100
99.6
90
93.9
N.A.
90
90
N.A.
N.A.
60.1
77.3
74.6
N.A.
63.8
N.A.
55.7
65
P-Site Identity:
100
100
100
86.6
N.A.
73.3
66.6
N.A.
N.A.
46.6
46.6
33.3
N.A.
40
N.A.
46.6
6.6
P-Site Similarity:
100
100
100
100
N.A.
86.6
80
N.A.
N.A.
66.6
80
66.6
N.A.
73.3
N.A.
60
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
34.3
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
56
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
26.6
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
66.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
16
8
39
0
0
0
8
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
47
0
0
47
8
0
0
0
0
0
0
8
0
0
8
% D
% Glu:
31
0
0
16
24
0
0
8
54
0
16
62
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
54
0
% F
% Gly:
8
0
8
0
0
0
0
0
0
0
8
0
0
8
8
% G
% His:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% H
% Ile:
0
8
0
0
0
0
0
8
0
77
0
0
0
0
0
% I
% Lys:
0
93
0
16
0
0
8
24
0
0
47
0
77
0
54
% K
% Leu:
0
0
93
0
0
8
0
0
0
24
8
8
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
24
0
0
0
16
16
0
0
0
0
0
16
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
39
0
0
0
8
0
0
8
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
16
0
0
8
0
8
0
0
% R
% Ser:
16
0
0
0
0
0
54
31
16
0
8
8
0
0
8
% S
% Thr:
0
0
0
0
0
8
0
0
0
0
0
0
16
0
0
% T
% Val:
0
0
0
0
16
70
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% W
% Tyr:
0
0
0
0
0
8
0
0
0
0
0
0
0
31
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _